Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells.
about
Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tailCo-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulationNef-mediated clathrin-coated pit formationThe association of Nef with a cellular serine/threonine kinase and its enhancement of infectivity are viral isolate dependentLentivirus Nef specifically activates Pak2.Simian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques.The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes.Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.A microfluidic device for practical label-free CD4(+) T cell counting of HIV-infected subjects.The proteolytic cleavage of human immunodeficiency virus type 1 Nef does not correlate with its ability to stimulate virion infectivity.Human immunodeficiency virus type 2 produces a defect in CD3-gamma gene transcripts similar to that observed for human immunodeficiency virus type 1.Sequence variations in human immunodeficiency virus type 1 Nef are associated with different stages of disease.Human immunodeficiency virus type 1 Nef-induced CD4 cell surface downregulation is inhibited by ikarugamycinRestoration of wild-type infectivity to human immunodeficiency virus type 1 strains lacking nef by intravirion reverse transcription.The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase.Reconstitution and molecular analysis of an active human immunodeficiency virus type 1 Nef/p21-activated kinase 2 complex.Expression of simian immunodeficiency virus nef in immune cells of transgenic mice leads to a severe AIDS-like disease.Defective accessory genes in a human immunodeficiency virus type 1-infected long-term survivor lacking recoverable virusInhibition of Nef- and phorbol ester-induced CD4 degradation by macrolide antibiotics.Murine leukemia virus envelope protein in transgenic-mouse serum blocks infection in vitroHigh frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection.Induction of phosphorylation of human immunodeficiency virus type 1 Nef and enhancement of CD4 downregulation by phorbol myristate acetateThe nef gene products of both simian and human immunodeficiency viruses enhance virus infectivity and are functionally interchangeable.Human immunodeficiency virus type 1 Nef does not alter T-cell sensitivity to antigen-specific stimulation.The amphotropic murine leukemia virus receptor gene encodes a 71-kilodalton protein that is induced by phosphate depletion.Human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus Nef use distinct but overlapping target sites for downregulation of cell surface CD4.Differential Ability of Primary HIV-1 Nef Isolates To Downregulate HIV-1 Entry Receptors.Pol-specific CD8+ T cells recognize simian immunodeficiency virus-infected cells prior to Nef-mediated major histocompatibility complex class I downregulation.Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways.Infectivity enhancement by human immunodeficiency virus type 1 Nef is independent of its association with a cellular serine/threonine kinaseAnalysis of human immunodeficiency virus type 1 nef gene sequences present in vivo.The human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection.HIV-1 Nef dimerization is required for Nef-mediated receptor downregulation and viral replication.HIV-1 Nef and T-cell activation: a history of contradictions.The human immunodeficiency virus type 1 nef gene can to a large extent replace simian immunodeficiency virus nef in vivo.Efficient class I major histocompatibility complex down-regulation by simian immunodeficiency virus Nef is associated with a strong selective advantage in infected rhesus macaques.Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain.Functional characterization of human immunodeficiency virus type 1 nef genes in patients with divergent rates of disease progression.HIV-1 Nef protein is secreted into vesicles that can fuse with target cells and virions.The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef.
P2860
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P2860
Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Nef from primary isolates of h ...... on in human and mouse T cells.
@ast
Nef from primary isolates of h ...... on in human and mouse T cells.
@en
type
label
Nef from primary isolates of h ...... on in human and mouse T cells.
@ast
Nef from primary isolates of h ...... on in human and mouse T cells.
@en
prefLabel
Nef from primary isolates of h ...... on in human and mouse T cells.
@ast
Nef from primary isolates of h ...... on in human and mouse T cells.
@en
P2093
P2860
P1433
P1476
Nef from primary isolates of h ...... ion in human and mouse T cells
@en
P2093
D C Shugars
J V Garcia
R Swanstrom
S Anderson
P2860
P304
P407
P577
1993-08-01T00:00:00Z