T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production.
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Role of the tumor microenvironment in mature B-cell lymphoid malignanciesImmunotherapy in Chronic Lymphocytic Leukaemia (CLL)Overcoming T cell exhaustion in infection and cancerPhenotypic T cell exhaustion in a murine model of bacterial infection in the setting of pre-existing malignancy'Trained immunity': consequences for lymphoid malignanciesCatching up with solid tumor oncology: what is the evidence for a prognostic role of programmed cell death-ligand 1/programmed cell death-1 expression in B-cell lymphomas?Phase I-II study of lenalidomide and alemtuzumab in refractory chronic lymphocytic leukemia (CLL): effects on T cells and immune checkpoints.T cells in chronic lymphocytic leukemia display dysregulated expression of immune checkpoints and activation markers.Using Murine Models to Investigate Tumor-Lymphoid Interactions: Spotlight on Chronic Lymphocytic Leukemia and Angioimmunoblastic T-Cell Lymphoma.Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia.Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo.Chronic lymphocytic leukemia patients have a preserved cytomegalovirus-specific antibody response despite progressive hypogammaglobulinemiaPossible role of minor h antigens in the persistence of donor chimerism after stem cell transplantation; relevance for sustained leukemia remissionPD-1+Tim-3+ CD8+ T Lymphocytes Display Varied Degrees of Functional Exhaustion in Patients with Regionally Metastatic Differentiated Thyroid CancerPD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemiaMechanisms of PD-L1/PD-1-mediated CD8 T-cell dysfunction in the context of aging-related immune defects in the Eµ-TCL1 CLL mouse model.Haematological malignancies: at the forefront of immunotherapeutic innovation.T cells are functionally not impaired in AML: increased PD-1 expression is only seen at time of relapse and correlates with a shift towards the memory T cell compartment.PD-1(hi)TIM-3(+) T cells associate with and predict leukemia relapse in AML patients post allogeneic stem cell transplantation.The role of the tumor microenvironment in HIV-associated lymphomasElevated Expression of CD160 and 2B4 Defines a Cytolytic HIV-Specific CD8+ T-Cell Population in Elite Controllers.T-cell number and subtype influence the disease course of primary chronic lymphocytic leukaemia xenografts in alymphoid mice.Idelalisib and caffeine reduce suppression of T cell responses mediated by activated chronic lymphocytic leukemia cells.Circulating and tumor-infiltrating Tim-3 in patients with colorectal cancer.Signaling pathway and dysregulation of PD1 and its ligands in lymphoid malignancies.Expression and function of the TL1A/DR3 axis in chronic lymphocytic leukemia.Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8+ Memory Stem Cells in Acquired Aplastic Anemia.Generating Peripheral Blood Derived Lymphocytes Reacting Against Autologous Primary AML Blasts.Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemiaArresting the Inflammatory Drive of Chronic Lymphocytic Leukemia with IbrutinibDisruption of in vivo Chronic Lymphocytic Leukemia Tumor-Microenvironment Interactions by Ibrutinib--Findings from an Investigator-Initiated Phase II StudyImproving therapy of chronic lymphocytic leukemia with chimeric antigen receptor T cellsChronic lymphocytic leukemia cells diversify and differentiate in vivo via a nonclassical Th1-dependent, Bcl-6-deficient processThe microenvironment of AIDS-related diffuse large B-cell lymphoma provides insight into the pathophysiology and indicates possible therapeutic strategiesTumor-Infiltrating T Cells and the PD-1 Checkpoint Pathway in Advanced Differentiated and Anaplastic Thyroid CancerCytomegalovirus infection does not impact on survival or time to first treatment in patients with chronic lymphocytic leukemiaT cells in multiple myeloma display features of exhaustion and senescence at the tumor site.Phenotypic alteration of CD8+ T cells in chronic lymphocytic leukemia is associated with epigenetic reprogramming.Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma.Ibrutinib efficacy and tolerability in patients with relapsed chronic lymphocytic leukemia following allogeneic HCT.
P2860
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P2860
T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
T cells from CLL patients exhi ...... acity for cytokine production.
@ast
T cells from CLL patients exhi ...... acity for cytokine production.
@en
type
label
T cells from CLL patients exhi ...... acity for cytokine production.
@ast
T cells from CLL patients exhi ...... acity for cytokine production.
@en
prefLabel
T cells from CLL patients exhi ...... acity for cytokine production.
@ast
T cells from CLL patients exhi ...... acity for cytokine production.
@en
P2093
P2860
P1433
P1476
T cells from CLL patients exhi ...... pacity for cytokine production
@en
P2093
Fabienne McClanahan
Jeffrey K Davies
John C Riches
John G Gribben
Rewas Fatah
Sameena Iqbal
Samir Agrawal
P2860
P304
P356
10.1182/BLOOD-2012-09-457531
P407
P577
2012-12-17T00:00:00Z