Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer
about
Genetic basis of glycogen storage disease type 1a: prevalent mutations at the glucose-6-phosphatase locusCpG island methylator phenotype in colorectal cancerAnalysis of repetitive element DNA methylation by MethyLight.Transitions at CpG dinucleotides, geographic clustering of TP53 mutations and food availability patterns in colorectal cancerA Syndromic Neurodevelopmental Disorder Caused by De Novo Variants in EBF3Transglutaminase-1 gene mutations in autosomal recessive congenital ichthyosis: summary of mutations (including 23 novel) and modeling of TGase-1Synthesis and properties of oligonucleotides containing 5-formyl-2'-deoxycytidine: in vitro DNA polymerase reactions on DNA templates containing 5-formyl-2'-deoxycytidine.DNA methylation: past, present and future directions.Epigenomic consequences of immortalized plant cell suspension culture.Lung cancer: a modified epigenome.Impact of transposable elements on the human genome.Roles of cell division and gene transcription in the methylation of CpG islands.SINE retroposons can be used in vivo as nucleation centers for de novo methylation.Recombinational and mutational hotspots within the human lipoprotein lipase geneMethylation and colorectal cancer.Cladistic structure within the human Lipoprotein lipase gene and its implications for phenotypic association studies.Gene silencing in mammalian cells and the spread of DNA methylation.Epigenetics in carcinogenesis and cancer prevention.DNA methylation, a biomarker for colorectal cancer: implications for screening and pathological utility.Cytosine methylation and mammalian developmentDynamic interrelationships between DNA replication, methylation, and repairIntronic TP53 Germline Sequence Variants Modify the Risk in German Breast/Ovarian Cancer Families.Cytosine methylation determines hot spots of DNA damage in the human P53 gene.The detection of K-ras mutations in colorectal cancer using the amplification-refractory mutation system.Damage-inducible intragenic demethylation of the human TP53 tumor suppressor gene is associated with transcription from an alternative intronic promoter.Metabolic defects provide a spark for the epigenetic switch in cancer.Enzymatic methylation of DNA in cultured human cells studied by stable isotope incorporation and mass spectrometry.The Warburg effect: molecular aspects and therapeutic possibilities.Mapping promoter regions that are hypersensitive to methylation-mediated inhibition of transcription: application of the methylation cassette assay to the Epstein-Barr virus major latency promoter.Barrett's esophagus. The significance of p53 in clinical practice.Clinical significance of p53 mutations in adenocarcinoma of the esophagus and cardia.A targeted-replacement system for identification of signals for de novo methylation in Neurospora crassa.Constitutively methylated CpG dinucleotides as mutation hot spots in the retinoblastoma gene (RB1).DNA methylation and carcinogenesis in digestive neoplasms.Alternative promoter identified between a hypermethylated upstream region of repetitive elements and a CpG island in human ABO histo-blood group genes.Enrichment for histone H3 lysine 9 methylation at Alu repeats in human cells.Correlation between global genome methylation and mutation at CpG codons of p53 gene.The unmethylated state of CpG islands in mouse fibroblasts depends on the poly(ADP-ribosyl)ation process.Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation.Epigenetic gene inactivation induced by a cis-acting methylation center.
P2860
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P2860
Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Ubiquitous and tenacious methy ...... ional hot spot in human cancer
@ast
Ubiquitous and tenacious methy ...... ional hot spot in human cancer
@en
type
label
Ubiquitous and tenacious methy ...... ional hot spot in human cancer
@ast
Ubiquitous and tenacious methy ...... ional hot spot in human cancer
@en
prefLabel
Ubiquitous and tenacious methy ...... ional hot spot in human cancer
@ast
Ubiquitous and tenacious methy ...... ional hot spot in human cancer
@en
P2860
P356
P1476
Ubiquitous and tenacious methy ...... ional hot spot in human cancer
@en
P2093
P2860
P304
P356
10.1128/MCB.14.6.4225
P407
P577
1994-06-01T00:00:00Z