The role of large-scale motions in catalysis by dihydrofolate reductase.
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Evidence that a 'dynamic knockout' in Escherichia coli dihydrofolate reductase does not affect the chemical step of catalysis.Unraveling the role of protein dynamics in dihydrofolate reductase catalysisDifferent dynamical effects in mesophilic and hyperthermophilic dihydrofolate reductases.Thermal adaptation of dihydrofolate reductase from the moderate thermophile Geobacillus stearothermophilus.Increased dynamic effects in a catalytically compromised variant of Escherichia coli dihydrofolate reductase.Direct observation of T4 lysozyme hinge-bending motion by fluorescence correlation spectroscopy.Are there dynamical effects in enzyme catalysis? Some thoughts concerning the enzymatic chemical step.Aliphatic (1)H, (13)C and (15)N chemical shift assignments of dihydrofolate reductase from the psychropiezophile Moritella profunda in complex with NADP(+) and folate.Benchmarking Quantum Mechanics/Molecular Mechanics (QM/MM) Methods on the Thymidylate Synthase-Catalyzed Hydride Transfer.Enzymes from piezophiles.Change in heat capacity accurately predicts vibrational coupling in enzyme catalyzed reactions.Protein motions and dynamic effects in enzyme catalysis.Minimization of dynamic effects in the evolution of dihydrofolate reductase† †Electronic supplementary information (ESI) available: Full experimental procedures; mass spectra of purified proteins; circular dichroism spectra, tabulated experimental dPrechemistry barriers and checkpoints do not contribute to fidelity and catalysis as long as they are not rate limiting
P2860
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P2860
The role of large-scale motions in catalysis by dihydrofolate reductase.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
The role of large-scale motions in catalysis by dihydrofolate reductase.
@ast
The role of large-scale motions in catalysis by dihydrofolate reductase.
@en
type
label
The role of large-scale motions in catalysis by dihydrofolate reductase.
@ast
The role of large-scale motions in catalysis by dihydrofolate reductase.
@en
prefLabel
The role of large-scale motions in catalysis by dihydrofolate reductase.
@ast
The role of large-scale motions in catalysis by dihydrofolate reductase.
@en
P2093
P2860
P50
P356
P1476
The role of large-scale motions in catalysis by dihydrofolate reductase
@en
P2093
Enas M Behiry
Lai-Hock Tey
Rudolf K Allemann
Sara B-M Whittaker
Ulrich L Günther
P2860
P304
20561-20570
P356
10.1021/JA208844J
P407
P577
2011-11-22T00:00:00Z