Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death.
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Innate immune interactions within the central nervous system modulate pathogenesis of viral infectionsModulation of Innate Immune Signalling by Lipid-Mediated MAVS Transmembrane Domain OligomerizationSARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter.Three-tier regulation of cell number plasticity by neurotrophins and Tolls in Drosophila.Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neuronsDLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injuryAge-dependent myeloid dendritic cell responses mediate resistance to la crosse virus-induced neurological disease.The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling.RNA-seq based transcriptome analysis of hepatitis E virus (HEV) and hepatitis B virus (HBV) replicon transfected Huh-7 cells.MAVS-MKK7-JNK2 defines a novel apoptotic signaling pathway during viral infection.Oropouche virus infection and pathogenesis are restricted by MAVS, IRF-3, IRF-7, and type I interferon signaling pathways in nonmyeloid cells.SARM1 activation triggers axon degeneration locally via NAD⁺ destructionSARM1, Not MyD88, Mediates TLR7/TLR9-Induced Apoptosis in Neurons.Sarm1-mediated axon degeneration requires both SAM and TIR interactionsEncephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis.SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation.Innate immune response to La Crosse virus infection.Wallerian degeneration: an emerging axon death pathway linking injury and disease.Innate immune responses regulate morphogenesis and degeneration: roles of Toll-like receptors and Sarm1 in neurons.Mitochondrial dynamics and the innate antiviral immune response.Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism.Capillaries in the olfactory bulb but not the cortex are highly susceptible to virus-induced vascular leak and promote viral neuroinvasion.Analysis of EV71 infection progression using triple-SILAC-based proteomics approach.Beyond TLR Signaling—The Role of SARM in Antiviral Immune Defense, Apoptosis & Development.TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target.Autophagy regulates MAVS signaling activation in a phosphorylation-dependent manner in microglia.Protective and Pathological Immunity during Central Nervous System Infections.Reduced Expression of SARM in Mouse Spleen during Polymicrobial Sepsis.Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative DisordersSARM is required for neuronal injury and cytokine production in response to central nervous system viral infection.Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury.Peroxisomes support human herpesvirus 8 latency by stabilizing the viral oncogenic protein vFLIP via the MAVS-TRAF complex.Human neural stem cell-derived neuron/astrocyte co-cultures respond to La Crosse virus infection with proinflammatory cytokines and chemokines
P2860
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P2860
Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Activation of the innate signa ...... M1, leading to neuronal death.
@ast
Activation of the innate signa ...... M1, leading to neuronal death.
@en
type
label
Activation of the innate signa ...... M1, leading to neuronal death.
@ast
Activation of the innate signa ...... M1, leading to neuronal death.
@en
prefLabel
Activation of the innate signa ...... M1, leading to neuronal death.
@ast
Activation of the innate signa ...... M1, leading to neuronal death.
@en
P2093
P2860
P1433
P1476
Activation of the innate signa ...... M1, leading to neuronal death.
@en
P2093
Piyali Mukherjee
Roger A Moore
Tyson A Woods
P2860
P304
P356
10.1016/J.IMMUNI.2013.02.013
P407
P577
2013-03-14T00:00:00Z