Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.
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Genetic profiling of the isoprenoid and sterol biosynthesis pathway genes of Trypanosoma cruziTargeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylaseGrowth inhibition and ultrastructural alterations induced by Delta24(25)-sterol methyltransferase inhibitors in Candida spp. isolates, including non-albicans organismsIsolation and identification of antitrypanosomal and antimycobacterial active steroids from the sponge Haliclona simulansNew azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action.Structures, targets and recent approaches in anti-leishmanial drug discovery and development.Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack.Interactions of antiparasitic sterols with sterol 14α-demethylase (CYP51) of human pathogensThe efficacy of 2-nitrovinylfuran derivatives against Leishmania in vitro and in vivoImipramine alters the sterol profile in Leishmania amazonensis and increases its sensitivity to miconazole.Novel antitrypanosomal agents.Fluorinated Sterols Are Suicide Inhibitors of Ergosterol Biosynthesis and Growth in Trypanosoma brucei.Quinuclidine derivatives as potential antiparasiticsAdaptations in the lipid metabolism of the protozoan parasite Trypanosoma brucei.Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth.Advances in Chagas disease drug development: 2009-2010Dynamics of sterol synthesis during development of Leishmania spp. parasites to their virulent form.Attenuation of Leishmania infantum chagasi metacyclic promastigotes by sterol depletionSterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs.Trypanocidal drugs: mechanisms, resistance and new targets.Drug targets in Leishmania.What has proteomics taught us about Leishmania development?Drug resistance in leishmaniasis: current drug-delivery systems and future perspectives.Antiproliferative, Ultrastructural, and Physiological Effects of Amiodarone on Promastigote and Amastigote Forms of Leishmania amazonensis.New parasite inhibitors encompassing novel conformationally-locked 5'-acyl sulfamoyl adenosines.In vitro activities of ER-119884 and E5700, two potent squalene synthase inhibitors, against Leishmania amazonensis: antiproliferative, biochemical, and ultrastructural effects.Ergosterone-coupled Triazol molecules trigger mitochondrial dysfunction, oxidative stress, and acidocalcisomal Ca2+ release in Leishmania mexicana promastigotes.Tomatidine promotes the inhibition of 24-alkylated sterol biosynthesis and mitochondrial dysfunction in Leishmania amazonensis promastigotes.The sesquiterpene (-)-α-bisabolol is active against the causative agents of Old World cutaneous leishmaniasis through the induction of mitochondrial-dependent apoptosis.CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase.Mechanistic analysis of a multiple product sterol methyltransferase implicated in ergosterol biosynthesis in Trypanosoma brucei.Arginine and Polyamines Fate in Leishmania Infection.Cholesterol import fails to prevent catalyst-based inhibition of ergosterol synthesis and cell proliferation of Trypanosoma brucei.Dermaseptin 01 as antimicrobial peptide with rich biotechnological potential: study of peptide interaction with membranes containing Leishmania amazonensis lipid-rich extract and membrane models
P2860
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P2860
Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.
@ast
Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.
@en
type
label
Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.
@ast
Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.
@en
prefLabel
Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.
@ast
Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.
@en
P2093
P2860
P50
P1476
Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis
@en
P2093
Carlos Rodrigues
Carmen Jiménez Jiménez
Juliany C F Rodrigues
Julio Urbina
Kate de Luca-Fradley
Miranda Joyce-Menekse
Silvia Orenes Lorente
Simon L Croft
Vanessa Yardley
Wanderley de Souza
P2860
P304
P356
10.1128/AAC.48.8.2937-2950.2004
P407
P577
2004-08-01T00:00:00Z