DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury. - Wikidata - awgldk - TriplyDB

DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury.

DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury.

http://www.wikidata.org/entity/Q36673264

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Regulation of Microtubule Dynamics in Axon Regeneration: Insights from C. elegans The DLK signalling pathway--a double-edged sword in neural development and regeneration RPM-1 uses both ubiquitin ligase and phosphatase-based mechanisms to regulate DLK-1 during neuronal development ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates Inhibiting poly(ADP-ribosylation) improves axon regeneration Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult.SkpA restrains synaptic terminal growth during development and promotes axonal degeneration following injury DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury Using microfluidics chips for live imaging and study of injury responses in Drosophila larvae.Axon injury and regeneration in the adult Drosophila Molecular mechanisms of the suppression of axon regeneration by KLF transcription factors.Preserve and protect: maintaining axons within functional circuits.RHGF-1/PDZ-RhoGEF and retrograde DLK-1 signaling drive neuronal remodeling on microtubule disassembly Retinal transcriptome profiling at transcription start sites: a cap analysis of gene expression early after axonal injury.Bimodal control of dendritic and axonal growth by the dual leucine zipper kinase pathway.RNA sequence reveals mouse retinal transcriptome changes early after axonal injury.Cytoskeletal disruption activates the DLK/JNK pathway, which promotes axonal regeneration and mimics a preconditioning injury.Akt suppresses DLK for maintaining self-renewal of mouse embryonic stem cells.Novel DLK-independent neuronal regeneration in Caenorhabditis elegans shares links with activity-dependent ectopic outgrowth.The Genetics of Axon Guidance and Axon Regeneration in Caenorhabditis elegans Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.Novel axon projection after stress and degeneration in the Dscam mutant retina Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death.GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway.Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in the Adult Central Nervous System.In vitro and in vivo neuroprotective effects of cJun N-terminal kinase inhibitors on retinal ganglion cells.Evaluation of the percentage of ganglion cells in the ganglion cell layer of the rodent retina An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK Independent pathways downstream of the Wnd/DLK MAPKKK regulate synaptic structure, axonal transport, and injury signaling JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis.Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons.Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury Loss of the spectraplakin short stop activates the DLK injury response pathway in Drosophila.Reconnecting Eye to Brain.Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration.Insulin/IGF1 signaling inhibits age-dependent axon regeneration.Mobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration.Regenerative Responses and Axon Pathfinding of Retinal Ganglion Cells in Chronically Injured Mice.Spatial and temporal dynamics of neurite regrowth.

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DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury.

http://www.wikidata.org/entity/Q36673264

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2013 nî lūn-bûn

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DLK initiates a transcriptiona ...... ve responses to axonal injury.

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DLK initiates a transcriptiona ...... ve responses to axonal injury.

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DLK initiates a transcriptiona ...... ve responses to axonal injury.

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DLK initiates a transcriptiona ...... ve responses to axonal injury.

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DLK initiates a transcriptiona ...... ve responses to axonal injury.

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PNAS.1211074110

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Proceedings of the National Academy of Sciences of the United States of America

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DLK initiates a transcriptiona ...... ive responses to axonal injury

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Bei Wang

http://www.w3.org/2001/XMLSchema#string

Joseph W Lewcock

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Joshua S Kaminker

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Marc Tessier-Lavigne

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Sarah Huntwork-Rodriguez

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Trent A Watkins

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Zhiyu Jiang

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P2860

Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway

Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

Identification of candidate transcriptional modulators involved in successful regeneration after nerve injury

The AP-1 transcription factor c-Jun is required for efficient axonal regeneration

Axon regeneration requires a conserved MAP kinase pathway.

Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration.

Changes in gene expression in experimental glaucoma and optic nerve transection: the equilibrium between protective and detrimental mechanisms.

The relationship between neuronal survival and regeneration.

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4039-4044

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10

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110

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Jeffrey Eastham-Anderson

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2013-02-19T00:00:00Z

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23431164

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apoptotic process

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3593899

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