A major role for Mcl-1 antiapoptotic protein in the IL-6-induced survival of human myeloma cells. - Wikidata - awgldk - TriplyDB

A major role for Mcl-1 antiapoptotic protein in the IL-6-induced survival of human myeloma cells.

A major role for Mcl-1 antiapoptotic protein in the IL-6-induced survival of human myeloma cells.

http://www.wikidata.org/entity/Q36675950

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Biological activity of lenalidomide and its underlying therapeutic effects in multiple myeloma Immediate early gene X-1 interacts with proteins that modulate apoptosis Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma Aryl hydrocarbon receptor (AhR) agonists suppress interleukin-6 expression by bone marrow stromal cells: an immunotoxicology study Targeting the apoptosis pathway in hematologic malignancies Circumvention of Mcl-1-dependent drug resistance by simultaneous Chk1 and MEK1/2 inhibition in human multiple myeloma cells High expression of Mcl-1 in ALK positive and negative anaplastic large cell lymphoma.A phase 2, randomized, double-blind, placebo-controlled study of siltuximab (anti-IL-6 mAb) and bortezomib versus bortezomib alone in patients with relapsed or refractory multiple myeloma.Induction of the interleukin 6/ signal transducer and activator of transcription pathway in the lungs of mice sub-chronically exposed to mainstream tobacco smoke.Nitric oxide induces cell death by regulating anti-apoptotic BCL-2 family members.Apoptosis of multiple myeloma.Gene expression of anti- and pro-apoptotic proteins in malignant and normal plasma cells.Myelomagenesis: capturing early microenvironment changes Silence of MCL-1 upstream signaling by shRNA abrogates multiple myeloma growth.Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytes.Mechanism of immunomodulatory drugs' action in the treatment of multiple myeloma.Survival and proliferation factors of normal and malignant plasma cells.The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival.Dendritic cells and malignant plasma cells: an alliance in multiple myeloma tumor progression?Growth factors and antiapoptotic signaling pathways in multiple myeloma.BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone Candidate genes of Waldenström's macroglobulinemia: current evidence and research.Gene expression-based prediction of myeloma cell sensitivity to histone deacetylase inhibitors.FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation.CD38 ligation in peripheral blood mononuclear cells of myeloma patients induces release of protumorigenic IL-6 and impaired secretion of IFNγ cytokines and proliferation.Inflammation and survival pathways: chronic lymphocytic leukemia as a model system.Through a glass less darkly: apoptosis and the germinal center response to antigen.Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis.MK2206 enhances the cytocidal effects of bufalin in multiple myeloma by inhibiting the AKT/mTOR pathway.The phosphatase of regenerating liver-3 (PRL-3) is important for IL-6-mediated survival of myeloma cells.Role of interleukin-6 in cancer progression and therapeutic resistance.Autocrine amplification of immature myeloid cells by IL-6 in multiple myeloma-infiltrated bone marrow.AT-101 downregulates BCL2 and MCL1 and potentiates the cytotoxic effects of lenalidomide and dexamethasone in preclinical models of multiple myeloma and Waldenström macroglobulinaemia.Identification of molecular vulnerabilities in human multiple myeloma cells by RNA interference lethality screening of the druggable genome Effects of native human leukocyte interferon-alpha and recombinant human interferon-alpha on P3-X63-Ag8.653 mouse myeloma cell growth.N-terminal truncation of antiapoptotic MCL1, but not G2/M-induced phosphorylation, is associated with stabilization and abundant expression in tumor cells.ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells.Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival.SDX-101, the R-enantiomer of etodolac, induces cytotoxicity, overcomes drug resistance, and enhances the activity of dexamethasone in multiple myeloma.p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells.

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A major role for Mcl-1 antiapoptotic protein in the IL-6-induced survival of human myeloma cells.

http://www.wikidata.org/entity/Q36675950

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A major role for Mcl-1 antiapo ...... rvival of human myeloma cells.

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A major role for Mcl-1 antiapo ...... rvival of human myeloma cells.

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A major role for Mcl-1 antiapo ...... rvival of human myeloma cells.

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Bernard Klein

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Guilhem Couderc

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Jean-Luc Veyrune

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John De Vos

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Michel Jourdan

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Nicole Redal

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P2860

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members

BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members

Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy.

IgG1 plasmacytosis in interleukin 6 transgenic mice.

Human and mouse chromosomal mapping of the myeloid cell leukemia-1 gene: MCL1 maps to human chromosome 1q21, a region that is frequently altered in preneoplastic and neoplastic disease.

MCL1 provides a window on the role of the BCL2 family in cell proliferation, differentiation and tumorigenesis.

Regulation of Bcl-2-family proteins in myeloma cells by three myeloma survival factors: interleukin-6, interferon-alpha and insulin-like growth factor 1.

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2396235

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