BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells - Wikidata - awgldk - TriplyDB

BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells

BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells

http://www.wikidata.org/entity/Q36677926

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Mitochondria, cholesterol and cancer cell metabolism Cancer stem cell metabolism Genetics and biology of pancreatic ductal adenocarcinoma Integration of Mitochondrial Targeting for Molecular Cancer Therapeutics Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance MYC, Metabolism, and Cancer Redox Regulation in Cancer Stem Cells Increased Oxidative Stress as a Selective Anticancer Therapy Treatment Strategies that Enhance the Efficacy and Selectivity of Mitochondria-Targeted Anticancer Agents Harnessing the apoptotic programs in cancer stem-like cells Concise review: Leukemia stem cells in personalized medicine Can nanomedicines kill cancer stem cells?Update on acute myeloid leukemia stem cells: New discoveries and therapeutic opportunities Cancer stem cell metabolism: a potential target for cancer therapy EMT, CTCs and CSCs in tumor relapse and drug-resistance Alternative Treatments For Melanoma: Targeting BCL-2 Family Members to De-Bulk and Kill Cancer Stem Cells Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer Therapies HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth A novel formulation of tigecycline has enhanced stability and sustained antibacterial and antileukemic activity Identification and Characterization of CXCR4-Positive Gastric Cancer Stem Cells A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia Mitochondrial control by DRP1 in brain tumor initiating cells.Selective Vulnerability of Cancer Cells by Inhibition of Ca(2+) Transfer from Endoplasmic Reticulum to Mitochondria The BCL2 inhibitor ABT-199 significantly enhances imatinib-induced cell death in chronic myeloid leukemia progenitors Head and Neck Squamous Cell Carcinoma Metabolism Draws on Glutaminolysis, and Stemness Is Specifically Regulated by Glutaminolysis via Aldehyde Dehydrogenase Role of NF-E2 related factor 2 (Nrf2) on chemotherapy resistance in acute myeloid leukemia (AML) and the effect of pharmacological inhibition of Nrf2 Efficacy and Biological Correlates of Response in a Phase II Study of Venetoclax Monotherapy in Patients with Acute Myelogenous Leukemia.Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation.Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells.Antineoplastic effects of CPPTL via the ROS/JNK pathway in acute myeloid leukemia.Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit.Metabolic differences in breast cancer stem cells and differentiated progeny.Flavaglines target primitive leukemia cells and enhance anti-leukemia drug activity.Reactive oxygen species in normal and tumor stem cells.Elimination of quiescent/slow-proliferating cancer stem cells by Bcl-XL inhibition in non-small cell lung cancer Glucose availability and glycolytic metabolism dictate glycosphingolipid levels Attacking the supply wagons to starve cancer cells to death.Metabolic reprogramming and epithelial-to-mesenchymal transition in cancer.New strategies in acute myelogenous leukemia: leukemogenesis and personalized medicine.

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P2860

BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells

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BCL-2 inhibition targets oxida ...... cent human leukemia stem cells

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Alexander Sach

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Craig T Jordan

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Eleni D Lagadinou

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Jane L Liesveld

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Kevin Callahan

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Kristen M O'Dwyer

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Mohammad Minhajuddin

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Paul S Brookes

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Randall M Rossi

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Sarah J Neering

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P2860

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

On the Origin of Cancer Cells

Mitochondrial fusion and fission in cell life and death

Regulation of cancer cell metabolism

FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

Association of reactive oxygen species levels and radioresistance in cancer stem cells

Energy metabolism in human pluripotent stem cells and their differentiated counterparts.

The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche.

Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rγc-deficient mice.

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329-341

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10.1016/J.STEM.2012.12.013

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Michael W Becker

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234699304

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phosphorylation

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3595363

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