Ontogeny of the v-erbA oncoprotein from the thyroid hormone receptor: an alteration in the DNA binding domain plays a role crucial for v-erbA function
about
Large-scale analysis by SAGE reveals new mechanisms of v-erbA oncogene action.Nuclear hormone receptors involved in neoplasia: erb A exhibits a novel DNA sequence specificity determined by amino acids outside of the zinc-finger domain.A conserved C-terminal sequence that is deleted in v-ErbA is essential for the biological activities of c-ErbA (the thyroid hormone receptor).The erbA oncogene represses the actions of both retinoid X and retinoid A receptors but does so by distinct mechanisms.Kindred S thyroid hormone receptor is an active and constitutive silencer and a repressor for thyroid hormone and retinoic acid responsesThyroid abnormalities and hepatocellular carcinoma in mice transgenic for v-erbA.Unliganded T3R, but not its oncogenic variant, v-erbA, suppresses RAR-dependent transactivation by titrating out RXR.Transcriptional repression of band 3 and CAII in v-erbA transformed erythroblasts accounts for an important part of the leukaemic phenotype.The glucocorticoid receptor is a key regulator of the decision between self-renewal and differentiation in erythroid progenitors.
P2860
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P2860
Ontogeny of the v-erbA oncoprotein from the thyroid hormone receptor: an alteration in the DNA binding domain plays a role crucial for v-erbA function
description
1991 nî lūn-bûn
@nan
1991年の論文
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1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Ontogeny of the v-erbA oncopro ...... le crucial for v-erbA function
@ast
Ontogeny of the v-erbA oncopro ...... le crucial for v-erbA function
@en
type
label
Ontogeny of the v-erbA oncopro ...... le crucial for v-erbA function
@ast
Ontogeny of the v-erbA oncopro ...... le crucial for v-erbA function
@en
prefLabel
Ontogeny of the v-erbA oncopro ...... le crucial for v-erbA function
@ast
Ontogeny of the v-erbA oncopro ...... le crucial for v-erbA function
@en
P2093
P2860
P1433
P1476
Ontogeny of the v-erbA oncopro ...... le crucial for v-erbA function
@en
P2093
M L Privalsky
P2860
P304
P407
P577
1991-04-01T00:00:00Z