An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo
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Synaptic Cell Adhesion Molecules in Alzheimer's DiseaseThe Cellular Prion Protein: A Player in Immunological QuiescenceInteraction between prion protein and Aβ amyloid fibrils revisitedActivation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo.Alzheimer's disease and prion proteinFunctions of the cellular prion protein, the end of Moore's law, and Ockham's razor theoryA sensitive and selective electrochemical biosensor for the determination of beta-amyloid oligomer by inhibiting the peptide-triggered in situ assembly of silver nanoparticles.Computational identification of potential multitarget treatments for ameliorating the adverse effects of amyloid-β on synaptic plasticityThe biological function of the cellular prion protein: an updateComplex proteinopathy with accumulations of prion protein, hyperphosphorylated tau, α-synuclein and ubiquitin in experimental bovine spongiform encephalopathy of monkeys.PrP overdrive: does inhibition of α-cleavage contribute to PrP(C) toxicity and prion disease?Identification of PrP sequences essential for the interaction between the PrP polymers and Aβ peptide in a yeast-based assayCellular prion protein and NMDA receptor modulation: protecting against excitotoxicity.The sheddase ADAM10 is a potent modulator of prion disease.Translation of the prion protein mRNA is robust in astrocytes but does not amplify during reactive astrocytosis in the mouse brainDextran sulfate sodium inhibits amyloid-β oligomer binding to cellular prion protein.Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's diseasePrion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models.Cellular prion protein (PrP(C)) and its role in stress responses.A Neuronal Culture System to Detect Prion Synaptotoxicity.QIAD assay for quantitating a compound's efficacy in elimination of toxic Aβ oligomersValidation and Characterization of a Novel Peptide That Binds Monomeric and Aggregated β-Amyloid and Inhibits the Formation of Neurotoxic Oligomers.A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein.Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's diseaseSoluble prion protein and its N-terminal fragment prevent impairment of synaptic plasticity by Aβ oligomers: Implications for novel therapeutic strategy in Alzheimer's disease.The Anti-Prion Antibody 15B3 Detects Toxic Amyloid-β OligomersA new paradigm for enzymatic control of α-cleavage and β-cleavage of the prion protein.Biophysical studies of the amyloid β-peptide: interactions with metal ions and small molecules.Taking advantage of physiological proteolytic processing of the prion protein for a therapeutic perspective in prion and Alzheimer diseases.The GPI-anchoring of PrP: implications in sorting and pathogenesis.Regulation of PrP(C) signaling and processing by dimerization.From Neurodegeneration to Brain Health: An Integrated Approach.The Essential Role of Soluble Aβ Oligomers in Alzheimer's Disease.α-Synuclein Amyloids Hijack Prion Protein to Gain Cell Entry, Facilitate Cell-to-Cell Spreading and Block Prion Replication.The cellular prion protein (PrPC) as neuronal receptor for α-synuclein.Identification of Anti-prion Compounds using a Novel Cellular Assay.Different Molecular Mechanisms Mediate Direct or Glia-Dependent Prion Protein Fragment 90-231 Neurotoxic Effects in Cerebellar Granule Neurons.Oligomeropathies and pathogenesis of Alzheimer and Parkinson's diseases.Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta-mediated neurotoxicity.Cross-interactions between the Alzheimer Disease Amyloid-β Peptide and Other Amyloid Proteins: A Further Aspect of the Amyloid Cascade Hypothesis.
P2860
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P2860
An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
An N-terminal fragment of the ...... ts their neurotoxicity in vivo
@ast
An N-terminal fragment of the ...... ts their neurotoxicity in vivo
@en
type
label
An N-terminal fragment of the ...... ts their neurotoxicity in vivo
@ast
An N-terminal fragment of the ...... ts their neurotoxicity in vivo
@en
prefLabel
An N-terminal fragment of the ...... ts their neurotoxicity in vivo
@ast
An N-terminal fragment of the ...... ts their neurotoxicity in vivo
@en
P2093
P2860
P50
P356
P1476
An N-terminal fragment of the ...... ts their neurotoxicity in vivo
@en
P2093
Alessandra Sclip
Brian R Fluharty
Claudia Balducci
Laura Colombo
Luisa Diomede
Massimo Messa
Pietro La Vitola
P2860
P304
P356
10.1074/JBC.M112.423954
P407
P577
2013-01-28T00:00:00Z