Prion strain discrimination in cell culture: the cell panel assay
about
Darwinian evolution of prions in cell cultureUnraveling prion strains with cell biology and organic chemistryPropagation of prions causing synucleinopathies in cultured cellsCellular aspects of prion replication in vitroThe strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of diseaseAcquisition of drug resistance and dependence by prionsTetracysteine-tagged prion protein allows discrimination between the native and converted formsIdentification of a gene regulatory network associated with prion replication.Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and websPathologic prion protein infects cells by lipid-raft dependent macropinocytosisPrion strain discrimination based on rapid in vivo amplification and analysis by the cell panel assayLipid rafts and clathrin cooperate in the internalization of PrP in epithelial FRT cellsLiposome-siRNA-peptide complexes cross the blood-brain barrier and significantly decrease PrP on neuronal cells and PrP in infected cell cultures.Infection of cell lines with experimental and natural ovine scrapie agents.Low density subcellular fractions enhance disease-specific prion protein misfolding.Manganese upregulates cellular prion protein and contributes to altered stabilization and proteolysis: relevance to role of metals in pathogenesis of prion diseaseA simple, versatile and sensitive cell-based assay for prions from various speciesSynthesis of high titer infectious prions with cofactor molecules.Cell-based quantification of chronic wasting disease prions.Axonal and transynaptic spread of prions.Spontaneous generation of mammalian prionsReport of the Working Group 'Overall Blood Supply Strategy with Regard to Variant Creutzfeldt-Jakob Disease (vCJD)': Statement on the Development and Implementation of Test Systems Suitable for the Screening of Blood Donors for vCJD - Dated SeptembeProtease-resistant prions selectively decrease Shadoo protein.Plasmacytoid dendritic cells sequester high prion titres at early stages of prion infection.Mutation and selection of prions.Propagation of RML prions in mice expressing PrP devoid of GPI anchor leads to formation of a novel, stable prion strainLymphotoxin, but not TNF, is required for prion invasion of lymph nodes.Transfer of a prion strain to different hosts leads to emergence of strain variants.A bovine cell line that can be infected by natural sheep scrapie prions.Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells.Replication and spread of CJD, kuru and scrapie agents in vivo and in cell cultureAlteration of the chronic wasting disease species barrier by in vitro prion amplification.Conformational transformation and selection of synthetic prion strains.High CJD infectivity remains after prion protein is destroyed.Infectious prion protein alters manganese transport and neurotoxicity in a cell culture model of prion disease.Prions on the move.Abrogation of complex glycosylation by swainsonine results in strain- and cell-specific inhibition of prion replication.A novel and rapid method for obtaining high titre intact prion strains from mammalian brain.Mutability of prions.Reaction of complement factors varies with prion strains in vitro and in vivo.
P2860
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P2860
Prion strain discrimination in cell culture: the cell panel assay
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Prion strain discrimination in cell culture: the cell panel assay
@ast
Prion strain discrimination in cell culture: the cell panel assay
@en
type
label
Prion strain discrimination in cell culture: the cell panel assay
@ast
Prion strain discrimination in cell culture: the cell panel assay
@en
prefLabel
Prion strain discrimination in cell culture: the cell panel assay
@ast
Prion strain discrimination in cell culture: the cell panel assay
@en
P2093
P2860
P356
P1476
Prion strain discrimination in cell culture: the cell panel assay
@en
P2093
Charles Weissmann
Cheryl A Demczyk
Christian Julius
Christopher A Baker
Emery W Smith
Sukhvir P Mahal
P2860
P304
20908-20913
P356
10.1073/PNAS.0710054104
P407
P577
2007-12-11T00:00:00Z