Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice
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Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice.Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase IIReduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behavior.Biochemical and structural properties of mouse kynurenine aminotransferase IIIMammalian nicotinic acetylcholine receptors: from structure to functionKynurenines in the mammalian brain: when physiology meets pathologyCrystal structure of human kynurenine aminotransferase IICrystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophreniaStructure, expression, and function of kynurenine aminotransferases in human and rodent brainsMitochondrial aspartate aminotransferase: a third kynurenate-producing enzyme in the mammalian brainThe BTBR T+ tf/J mouse model for autism spectrum disorders-in search of biomarkers.Autism-like behavioral phenotypes in BTBR T+tf/J miceNeonatal infection with neurotropic influenza A virus induces the kynurenine pathway in early life and disrupts sensorimotor gating in adult Tap1-/- mice.Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferasesAge dependency of inhibition of alpha7 nicotinic receptors and tonically active N-methyl-D-aspartate receptors by endogenously produced kynurenic acid in the brainA mathematical model of tryptophan metabolism via the kynurenine pathway provides insights into the effects of vitamin B-6 deficiency, tryptophan loading, and induction of tryptophan 2,3-dioxygenase on tryptophan metabolitesUnderstanding the roles of the kynurenine pathway in multiple sclerosis progression.Elevated kynurenine pathway metabolism during neurodevelopment: Implications for brain and behavior.Kynurenines and Glutamate: Multiple Links and Therapeutic Implications.Astrocytic and neuronal localization of kynurenine aminotransferase-2 in the adult mouse brain.Efficient gene-targeting in rat embryonic stem cells by CRISPR/Cas and generation of human kynurenine aminotransferase II (KAT II) knock-in rat.Structure of the PLP-Form of the Human Kynurenine Aminotransferase II in a Novel Spacegroup at 1.83 Å Resolution.Cortical kynurenic acid bi-directionally modulates prefrontal glutamate levels as assessed by microdialysis and rapid electrochemistry.Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum.Xanthurenic Acid Formation from 3-Hydroxykynurenine in the Mammalian Brain: Neurochemical Characterization and Physiological Effects.Quantitative Analysis of Kynurenine Aminotransferase II in the Adult Rat Brain Reveals High Expression in Proliferative Zones and Corpus Callosum.High resolution crystal structures of human kynurenine aminotransferase-I bound to PLP cofactor, and in complex with aminooxyacetate.
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P2860
Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice
@ast
Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice
@en
type
label
Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice
@ast
Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice
@en
prefLabel
Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice
@ast
Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice
@en
P2093
P2860
P1476
Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice
@en
P2093
Danilo A Tagle
Michael T Sapko
Miguel Melendez-Ferro
Nicholas A Di Prospero
Paolo Guidetti
Robert Schwarcz
William O Whetsell
P2860
P304
P356
10.1128/MCB.24.16.6919-6930.2004
P407
P50
P577
2004-08-01T00:00:00Z