The synthesis of UDP-N-acetylglucosamine is essential for bloodstream form trypanosoma brucei in vitro and in vivo and UDP-N-acetylglucosamine starvation reveals a hierarchy in parasite protein glycosylation.
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Sugar activation and glycosylation in PlasmodiumGenetic and structural validation ofAspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal targetA Novel Allosteric Inhibitor of the Uridine Diphosphate N -Acetylglucosamine Pyrophosphorylase from Trypanosoma bruceiHigh-confidence glycosome proteome for procyclic form Trypanosoma brucei by epitope-tag organelle enrichment and SILAC proteomics.Locating sweet spots for screening hits and evaluating pan-assay interference filters from the performance analysis of two lead-like librariesExposure of Trypanosoma brucei to an N-acetylglucosamine-binding lectin induces VSG switching and glycosylation defects resulting in reduced infectivity.Identification, subcellular localization, biochemical properties, and high-resolution crystal structure of Trypanosoma brucei UDP-glucose pyrophosphorylaseTranscriptomic profiling of host-parasite interactions in the microsporidian Trachipleistophora hominisIdentification of a Golgi-localized UDP-N-acetylglucosamine transporter in Trypanosoma cruzi.The de novo and salvage pathways of GDP-mannose biosynthesis are both sufficient for the growth of bloodstream-form Trypanosoma brucei.Inhibition of nucleotide sugar transport in Trypanosoma brucei alters surface glycosylation.A Gene of the β3-Glycosyltransferase Family Encodes N-Acetylglucosaminyltransferase II Function in Trypanosoma bruceiDistinct donor and acceptor specificities of Trypanosoma brucei oligosaccharyltransferases.Intermediary metabolism in protists: a sequence-based view of facultative anaerobic metabolism in evolutionarily diverse eukaryotes.Harnessing allostery: a novel approach to drug discovery.Identification of a glycosylphosphatidylinositol anchor-modifying β1-3 galactosyltransferase in Trypanosoma bruceiCarbohydrate-binding agents act as potent trypanocidals that elicit modifications in VSG glycosylation and reduced virulence in Trypanosoma brucei.The lipid-linked oligosaccharide donor specificities of Trypanosoma brucei oligosaccharyltransferases.Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted by phosphomannomutase and phospho-N-acetylglucosamine mutase.Trypanosoma brucei UDP-glucose:glycoprotein glucosyltransferase has unusual substrate specificity and protects the parasite from stress.Characterization, localization, essentiality, and high-resolution crystal structure of glucosamine 6-phosphate N-acetyltransferase from Trypanosoma brucei.Substrate Specificity and Inhibitor Sensitivity of Plant UDP-Sugar Producing Pyrophosphorylases.Identification of a novel UDP-sugar pyrophosphorylase with a broad substrate specificity in Trypanosoma cruzi.The Apicomplexa-specific glucosamine-6-phosphate N-acetyltransferase gene family encodes a key enzyme for glycoconjugate synthesis with potential as therapeutic target
P2860
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P2860
The synthesis of UDP-N-acetylglucosamine is essential for bloodstream form trypanosoma brucei in vitro and in vivo and UDP-N-acetylglucosamine starvation reveals a hierarchy in parasite protein glycosylation.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
The synthesis of UDP-N-acetylg ...... arasite protein glycosylation.
@ast
The synthesis of UDP-N-acetylg ...... arasite protein glycosylation.
@en
type
label
The synthesis of UDP-N-acetylg ...... arasite protein glycosylation.
@ast
The synthesis of UDP-N-acetylg ...... arasite protein glycosylation.
@en
prefLabel
The synthesis of UDP-N-acetylg ...... arasite protein glycosylation.
@ast
The synthesis of UDP-N-acetylg ...... arasite protein glycosylation.
@en
P2093
P2860
P921
P356
P1476
The synthesis of UDP-N-acetylg ...... parasite protein glycosylation
@en
P2093
Daniel C Turnock
Kirstee L Martin
M Lucia S Güther
Magnus S Alphey
Matthew J Stokes
P2860
P304
16147-16161
P356
10.1074/JBC.M709581200
P407
P577
2008-04-01T00:00:00Z