Wnt signaling and human diseases: what are the therapeutic implications? - Wikidata - awgldk - TriplyDB

Wnt signaling and human diseases: what are the therapeutic implications?

Wnt signaling and human diseases: what are the therapeutic implications?

http://www.wikidata.org/entity/Q36702732

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Glycogen synthase kinase 3: more than a namesake Sulindac suppresses beta-catenin expression in human cancer cells Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins Wnt pathway activation increases hypoxia tolerance during development Prediction of potential drug targets based on simple sequence properties.Liposomal packaging generates Wnt protein with in vivo biological activity Activation of RXR and RAR signaling promotes myogenic differentiation of myoblastic C2C12 cells Wnt and BMP Signaling Crosstalk in Regulating Dental Stem Cells: Implications in Dental Tissue Engineering.Noncanonical Wnt signaling plays an important role in modulating canonical Wnt-regulated stemness, proliferation and terminal differentiation of hepatic progenitors.Destabilization of heterologous proteins mediated by the GSK3β phosphorylation domain of the β-catenin protein Tumor inhibition by sodium selenite is associated with activation of c-Jun NH2-terminal kinase 1 and suppression of beta-catenin signaling.The CCN proteins: important signaling mediators in stem cell differentiation and tumorigenesis.Wnt2 expression and signaling is increased by different classes of antidepressant treatments.Glycogen synthase kinase-3β is associated with the prognosis of hepatocellular carcinoma and may mediate the influence of type 2 diabetes mellitus on hepatocellular carcinoma.MicroRNA-34a inhibits the proliferation and metastasis of osteosarcoma cells both in vitro and in vivo.Wnt activation by wild type and mutant myocilin in cultured human trabecular meshwork cells.Black raspberries inhibit intestinal tumorigenesis in apc1638+/- and Muc2-/- mouse models of colorectal cancer A simplified and versatile system for the simultaneous expression of multiple siRNAs in mammalian cells using Gibson DNA Assembly Tetrandrine inhibits Wnt/β-catenin signaling and suppresses tumor growth of human colorectal cancer Specific mutations in the beta-catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors.The Wnt signaling pathway: implications for therapy in osteosarcoma.Canonical Wnt signaling acts synergistically on BMP9-induced osteo/odontoblastic differentiation of stem cells of dental apical papilla (SCAPs).Biology of colorectal cancer.Defective osteogenic differentiation in the development of osteosarcoma.Mesenchymal stem cells: Molecular characteristics and clinical applications.Comprehensive annotation of microRNA expression profiles.A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells.Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment.Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation.TqPCR: A Touchdown qPCR Assay with Significantly Improved Detection Sensitivity and Amplification Efficiency of SYBR Green qPCR.Prognostic significance of cadherin-based adhesion molecules in cutaneous malignant melanoma Chemoprevention in gastrointestinal physiology and disease. Anti-inflammatory approaches for colorectal cancer chemoprevention Lysophosphatidic Acid Initiates Epithelial to Mesenchymal Transition and Induces β-Catenin-mediated Transcription in Epithelial Ovarian Carcinoma.Increased nuclear β-catenin expression in oral potentially malignant lesions: A marker of epithelial dysplasia Highly expressed UNC119 promotes hepatocellular carcinoma cell proliferation through Wnt/β-catenin signaling and predicts a poor prognosis The Current and Future Therapies for Human Osteosarcoma.The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies Origin and evolution of dishevelled.Osteosarcoma development and stem cell differentiation The functions and possible significance of Kremen as the gatekeeper of Wnt signalling in development and pathology.

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Wnt signaling and human diseases: what are the therapeutic implications?

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Wnt signaling and human diseases: what are the therapeutic implications?

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Laboratory Investigation

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Wnt signaling and human diseases: what are the therapeutic implications?

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Hue H Luu

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Jin Chen

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Jinyong Luo

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Katie A Sharff

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Ni Tang

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Rex C Haydon

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Tong-Chuan He

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Wen-Xin Song

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Xiaoji Luo

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Zhong-Liang Deng

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P2860

Inhibition of adipogenesis by Wnt signaling

Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy

Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family

Identification of c-MYC as a target of the APC pathway

Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q.

Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy

Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer

CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

A protein knockdown strategy to study the function of beta-catenin in tumorigenesis

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10.1038/LABINVEST.3700509

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2

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17211410

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