Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1. - Wikidata - awgldk - TriplyDB

Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1.

Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1.

http://www.wikidata.org/entity/Q36710634

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Inhibition of Mitochondrial p53 Accumulation by PFT-μ Prevents Cisplatin-Induced Peripheral Neuropathy.[EXPRESS] Epac and Nociceptor Sensitization.Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1.Inhibition of Epac1 suppresses mitochondrial fission and reduces neointima formation induced by vascular injury.Molecular mechanisms of the analgesic action of Wu-tou Decoction on neuropathic pain in mice revealed using microarray and network analysis.Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets.Adrenergic signaling in heart failure and cardiovascular aging.Piezo2 in Cutaneous and Proprioceptive Mechanotransduction in Vertebrates.A cell-based, quantitative and isoform-specific assay for exchange proteins directly activated by cAMP.Molecular Mechanisms That Contribute to Bone Marrow Pain Structure-activity relationships of 2-substituted phenyl-N-phenyl-2-oxoacetohydrazonoyl cyanides as novel antagonists of exchange proteins directly activated by cAMP (EPACs).An Orally Active Epac Inhibitor Reverses Mechanical Allodynia and Loss of Intraepidermal Nerve Fibers \iIn A Mouse Model of Chemotherapy-Induced Peripheral Neuropathy.Signalling transduction events involved in agonist-induced PGE2/EP4 receptor externalization in cultured rat dorsal root ganglion neurons.Mechanically sensitive Aδ nociceptors that innervate bone marrow respond to changes in intra-osseous pressure.The Potential of a Novel Class of EPAC-Selective Agonists to Combat Cardiovascular Inflammation.Role of exchange protein directly activated by cAMP (EPAC1) in breast cancer cell migration and apoptosis.Identification of FAM173B as a protein methyltransferase promoting chronic pain.Peripheral afferents and spinal inhibitory system in dynamic and static mechanical allodynia.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.Low GRK2 Underlies Hyperalgesic Priming by Glial Cell-Derived Neurotrophic Factor.

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P2860

Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1.

http://www.wikidata.org/entity/Q36710634

description

2016 nî lūn-bûn

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年论文

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2016年论文

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2016年论文

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name

Critical role for Epac1 in inf ...... ated phosphorylation of Epac1.

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Critical role for Epac1 in inf ...... ated phosphorylation of Epac1.

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Critical role for Epac1 in inf ...... ated phosphorylation of Epac1.

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Critical role for Epac1 in inf ...... ated phosphorylation of Epac1.

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Critical role for Epac1 in inf ...... ated phosphorylation of Epac1.

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Critical role for Epac1 in inf ...... ated phosphorylation of Epac1.

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PNAS.1516036113

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Critical role for Epac1 in inf ...... iated phosphorylation of Epac1

@en

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Annemieke Kavelaars

http://www.w3.org/2001/XMLSchema#string

Cobi J Heijnen

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Cristina Murga

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David Hawke

http://www.w3.org/2001/XMLSchema#string

Faiza Baameur

http://www.w3.org/2001/XMLSchema#string

Fang C Mei

http://www.w3.org/2001/XMLSchema#string

Federico Mayor

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Pooja Singhmar

http://www.w3.org/2001/XMLSchema#string

Susana Rojo Berciano

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XiaoJiao Huo

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P2860

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

A family of cAMP-binding proteins that directly activate Rap1

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels

Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions

Structure and regulation of the cAMP-binding domains of Epac2

A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase

Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia

A fluorescence-based high-throughput assay for the discovery of exchange protein directly activated by cyclic AMP (EPAC) antagonists

P304

3036-3041

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scholarly article

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10.1073/PNAS.1516036113

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11

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113

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Niels Eijkelkamp

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2016-02-29T00:00:00Z

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296468365

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26929333

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phosphorylation

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4801297

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