Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules
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Defining the blanks--pharmacochaperoning of SLC6 transporters and ABC transportersThe pharmacological impact of ATP-binding cassette drug transporters on vemurafenib-based therapyCFTR Modulators: Shedding Light on Precision Medicine for Cystic FibrosisReview: Gout: A Roadmap to Approaches for Improving Global OutcomesABCG2: the molecular mechanisms of urate secretion and goutJump into a New Fold-A Homology Based Model for the ABCG2/BCRP Multidrug TransporterGenome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.ABCG2 polymorphisms in gout: insights into disease susceptibility and treatment approachesFunctional polymorphisms of the ABCG2 gene are associated with gout disease in the Chinese Han male populationAn update on the genetic architecture of hyperuricemia and goutGenome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response.Deletion of Phenylalanine 508 in the First Nucleotide-binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator Increases Conformational Exchange and Inhibits Dimerization.Genetic and Dietary Regulation of Glyburide Efflux by the Human Placental Breast Cancer Resistance Protein TransporterMutations in intracellular loops 1 and 3 lead to misfolding of human P-glycoprotein (ABCB1) that can be rescued by cyclosporine A, which reduces its association with chaperone Hsp70.Clinical characteristics of early- and late-onset gout: A cross-sectional observational study from a Chinese gout clinic.Influence of the ABCG2 gout risk 141 K allele on urate metabolism during a fructose challenge.Structure and function of BCRP, a broad specificity transporter of xenobiotics and endobiotics.Association between ABCG2 Q141K polymorphism and gout risk affected by ethnicity and gender: a systematic review and meta-analysis.Regulatory-auxiliary subunits of CLC chloride channel-transport proteins.Recent advances in the exploration of the bile salt export pump (BSEP/ABCB11) function.The genetic basis of antiplatelet and anticoagulant therapy: A pharmacogenetic review of newer antiplatelets (clopidogrel, prasugrel and ticagrelor) and anticoagulants (dabigatran, rivaroxaban, apixaban and edoxaban).Contrasting roles of the ABCG2 Q141K variant in prostate cancer.A comprehensive analysis of the association of common variants of ABCG2 with gout.Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences.The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion.Metabolic Interactions of Purine Derivatives with Human ABC Transporter ABCG2: Genetic Testing to Assess Gout RiskRecent advances on uric acid transporters.ABCG2 as a therapeutic target candidate for gout.Population-Specific Resequencing Associates the ATP-Binding Cassette Subfamily C Member 4 Gene With Gout in New Zealand Māori and Pacific Men.Residues contributing to drug transport by ABCG2 are localised to multiple drug-binding pockets.Generation of multidrug resistant human tissues by overexpression of the ABCG2 multidrug transporter in embryonic stem cells.Twenty-eight loci that influence serum urate levels: analysis of association with gout.Clinically relevant mutations in the ABCG2 transporter uncovered by genetic analysis linked to erythrocyte membrane protein expression.Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy.
P2860
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P2860
Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Gout-causing Q141K mutation in ...... corrected with small molecules
@ast
Gout-causing Q141K mutation in ...... corrected with small molecules
@en
type
label
Gout-causing Q141K mutation in ...... corrected with small molecules
@ast
Gout-causing Q141K mutation in ...... corrected with small molecules
@en
prefLabel
Gout-causing Q141K mutation in ...... corrected with small molecules
@ast
Gout-causing Q141K mutation in ...... corrected with small molecules
@en
P2093
P2860
P356
P1476
Gout-causing Q141K mutation in ...... corrected with small molecules
@en
P2093
Anjana Rao
Benjamin S Parker
Deepali N Tukaye
Jinming Cui
Leeza M Constantoulakis
Michael Köttgen
Owen M Woodward
Patrick Greenwell
Peter C Maloney
William B Guggino
P2860
P304
P356
10.1073/PNAS.1214530110
P407
P577
2013-03-14T00:00:00Z