Engineered biosynthesis of a complete macrolactone in a heterologous host.
about
Heterologous expression of epothilone biosynthetic genes in Myxococcus xanthus.Combinatorial biosynthesis of polyketides--a perspective.Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.A multiplasmid approach to preparing large libraries of polyketides.Artificial chromosomes for antibiotic-producing actinomycetes.Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts.Shotgun cloning and heterologous expression of the patellamide gene cluster as a strategy to achieving sustained metabolite production.Heterologous expression of the oxytetracycline biosynthetic pathway in Myxococcus xanthus.Microbial polyketide synthases: more and more prolific.Pseudomonas syringae phytotoxins: mode of action, regulation, and biosynthesis by peptide and polyketide synthetasesNovel macrolides through genetic engineering.Emerging strategies and integrated systems microbiology technologies for biodiscovery of marine bioactive compounds.Biosynthesis of polyketides in heterologous hostsA stilbene synthase from Japanese red pine (Pinus densiflora): implications for phytoalexin accumulation and down-regulation of flavonoid biosynthesis.Manzamines: a potential for novel cures.Engineered polyketide biosynthesis and biocatalysis in Escherichia coli.Alternative sigma factor over-expression enables heterologous expression of a type II polyketide biosynthetic pathway in Escherichia coli.Expression of a functional fungal polyketide synthase in the bacterium Streptomyces coelicolor A3(2).Engineered biosynthesis of natural products in heterologous hostsMultiplexed integrating plasmids for engineering of the erythromycin gene cluster for expression in Streptomyces spp. and combinatorial biosynthesis.Combinatorial biosynthesis of reduced polyketides.The type I fatty acid and polyketide synthases: a tale of two megasynthasesRings, radicals, and regeneration: the early years of a bioorganic laboratoryEvolutionally guided enzyme design.Heterologous expression systems for polyketide synthases.In vitro reconstitution and analysis of the 6-deoxyerythronolide B synthase.Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis.The role of transcription in heterologous expression of polyketides in bacterial hosts.Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate?Conversion of the high-yield salinomycin producer Streptomyces albus BK3-25 into a surrogate host for polyketide production.Assembly of large genomic segments in artificial chromosomes by homologous recombination in Escherichia coli.Pristinamycin I biosynthesis in Streptomyces pristinaespiralis: molecular characterization of the first two structural peptide synthetase genesProduction of the potent antibacterial polyketide erythromycin C in Escherichia coli.Metabolic engineering--a genetic toolbox for small molecule organic synthesis.Production of the polyketide 6-deoxyerythronolide B in the heterologous host Bacillus subtilis.Engineering antibiotic producers to overcome the limitations of classical strain improvement programs.Rapid engineering of the geldanamycin biosynthesis pathway by Red/ET recombination and gene complementationCharacterization of a large, stable, high-copy-number Streptomyces plasmid that requires stability and transfer functions for heterologous polyketide overproduction.Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1.Biosynthetic multitasking facilitates thalassospiramide structural diversity in marine bacteria.
P2860
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P2860
Engineered biosynthesis of a complete macrolactone in a heterologous host.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Engineered biosynthesis of a complete macrolactone in a heterologous host.
@ast
Engineered biosynthesis of a complete macrolactone in a heterologous host.
@en
type
label
Engineered biosynthesis of a complete macrolactone in a heterologous host.
@ast
Engineered biosynthesis of a complete macrolactone in a heterologous host.
@en
prefLabel
Engineered biosynthesis of a complete macrolactone in a heterologous host.
@ast
Engineered biosynthesis of a complete macrolactone in a heterologous host.
@en
P2093
P356
P1433
P1476
Engineered biosynthesis of a complete macrolactone in a heterologous host.
@en
P2093
P304
P356
10.1126/SCIENCE.8036492
P407
P577
1994-07-01T00:00:00Z