v-Src increases diacylglycerol levels via a type D phospholipase-mediated hydrolysis of phosphatidylcholine.
about
Elevated phospholipase D activity in H-Ras- but not K-Ras-transformed cells by the synergistic action of RalA and ARF6Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3KRole for phospholipase D in receptor-mediated endocytosisRequirement of phospholipase D1 activity in H-RasV12-induced transformationAntagonistic effects of protein kinase C alpha and delta on both transformation and phospholipase D activity mediated by the epidermal growth factor receptor.Phospholipase D and RalA cooperate with the epidermal growth factor receptor to transform 3Y1 rat fibroblastsPhospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR)Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancerHeterogeneity of phosphatidic acid levels and distribution at the plasma membrane in living cells as visualized by a Föster resonance energy transfer (FRET) biosensorPhospholipase D controls Dictyostelium development by regulating G protein signaling.Functional association between Arf and RalA in active phospholipase D complex.Diacylglycerol Kinase ζ (DGKζ) Is a Critical Regulator of Bone Homeostasis Via Modulation of c-Fos Levels in Osteoclasts.Mutation of Y179 on phospholipase D2 (PLD2) upregulates DNA synthesis in a PI3K-and Akt-dependent manner.Activation of intracellular kinases in Xenopus oocytes by p21ras and phospholipases: a comparative study.Tumor promotion by depleting cells of protein kinase C delta.Phase I and pharmacologic study of CT-2584 HMS, a modulator of phosphatidic acid, in adult patients with solid tumoursEvidence that v-Src-induced phospholipase D activity is mediated by a G protein.Phospholipase D elevates the level of MDM2 and suppresses DNA damage-induced increases in p53.A GEF-to-phospholipase molecular switch caused by phosphatidic acid, Rac and JAK tyrosine kinase that explains leukocyte cell migrationIn skeletal muscle advanced glycation end products (AGEs) inhibit insulin action and induce the formation of multimolecular complexes including the receptor for AGEs.PLD2 has both enzymatic and cell proliferation-inducing capabilities, that are differentially regulated by phosphorylation and dephosphorylation.Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells.Alternative phospholipase D/mTOR survival signal in human breast cancer cells.Inhibitors of phospholipid intracellular signaling as antiproliferative agents.Activation of phospholipase D activity in transforming growth factor-beta-induced cell growth inhibition.Regulation of proliferation and apoptosis by Ras and Rho GTPases through specific phospholipid-dependent signaling.Activation of phospholipase D by ras proteins is independent of protein kinase C.Small GTPase-regulated phospholipase D in granulocytes.Temporal regulation of the IgE-dependent 1,2-diacylglycerol production by tyrosine kinase activation in a rat (RBL 2H3) mast-cell line.Activation of phospholipase C-gamma 1 through transfected platelet-derived growth factor receptor enhances interleukin 2 production upon antigen stimulation in a T-cell line.Modulation of pp60v-src and pp60c-src expression in Rous sarcoma virus-transformed hamster fibroblasts transfected with activated N-ras.Cholecystokinin-stimulated protein kinase C-delta kinase activation, tyrosine phosphorylation, and translocation are mediated by Src tyrosine kinases in pancreatic acinar cells.Activation of phospholipase D by growth factors and oncogenes in murine fibroblasts follow alternative but cross-talking pathways.Distinct mechanisms of phospholipase D activation and attenuation utilized by different mitogens in NIH-3T3 fibroblasts.ras-p21 activates phospholipase D and A2, but not phospholipase C or PKC, in Xenopus laevis oocytes.v-Src activates a unique phospholipase D activity that can be distinguished from the phospholipase D activity activated by phorbol estersRalA requirement for v-Src- and v-Ras-induced tumorigenicity and overproduction of urokinase-type plasminogen activator: involvement of metalloproteases.The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras.Ras mediates the activation of phospholipase D by v-Src.Phospholipase-induced maturation of Xenopus laevis oocytes: mitogenic activity of generated metabolites.
P2860
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P2860
v-Src increases diacylglycerol levels via a type D phospholipase-mediated hydrolysis of phosphatidylcholine.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
v-Src increases diacylglycerol ...... olysis of phosphatidylcholine.
@ast
v-Src increases diacylglycerol ...... olysis of phosphatidylcholine.
@en
type
label
v-Src increases diacylglycerol ...... olysis of phosphatidylcholine.
@ast
v-Src increases diacylglycerol ...... olysis of phosphatidylcholine.
@en
prefLabel
v-Src increases diacylglycerol ...... olysis of phosphatidylcholine.
@ast
v-Src increases diacylglycerol ...... olysis of phosphatidylcholine.
@en
P2093
P2860
P356
P1476
v-Src increases diacylglycerol ...... olysis of phosphatidylcholine.
@en
P2093
P2860
P304
P356
10.1128/MCB.11.10.4903
P407
P577
1991-10-01T00:00:00Z