Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging.
about
Unified theory of Alzheimer's disease (UTAD): implications for prevention and curative therapyLifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycinBig mice die young but large animals live longerComputer-aided discovery of biological activity spectra for anti-aging and anti-cancer olive oil oleuropeins.Latest progress in tyrosine kinase inhibitorsUSP9X deubiquitylating enzyme maintains RAPTOR protein levels, mTORC1 signalling and proliferation in neural progenitors.Aging and DNA damage in humans: a meta‐analysis study.TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists.Gerosuppression in confluent cells.Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat dietSex differences in aging, life span and spontaneous tumorigenesis in 129/Sv mice neonatally exposed to metformin.Telomerase deficiency delays renal recovery in mice after ischemia-reperfusion injury by impairing autophagyFasting levels of hepatic p-S6 are increased in old miceComparison of rapamycin schedules in mice on high-fat diet.Target of rapamycin activation predicts lifespan in fruit flies.IGF1R levels in the brain negatively correlate with longevity in 16 rodent species.Common drugs and treatments for cancer and age-related diseases: revitalizing answers to NCI's provocative questions.mTOR pathway and Ca²⁺ stores mobilization in aged smooth muscle cellsRapamycin increases grip strength and attenuates age-related decline in maximal running distance in old low capacity runner rats.Inverse correlation between longevity and developmental rate among wild C. elegans strains.M(o)TOR of aging: MTOR as a universal molecular hypothalamusEarly and extraordinary peaks in physical performance come with a longevity cost.Dysregulation of the mTOR pathway in p53-deficient mice.Birth mass is the key to understanding the negative correlation between lifespan and body size in dogs.Gerometabolites: the pseudohypoxic aging side of cancer oncometabolites.Somatic growth, aging, and longevity.Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome.Hamartoma-like lesions in the mouse retina: an animal model of Pten hamartoma tumour syndrome.
P2860
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P2860
Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging.
description
2012 nî lūn-bûn
@nan
2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Mechanistic or mammalian targe ...... the cost of accelerated aging.
@ast
Mechanistic or mammalian targe ...... the cost of accelerated aging.
@en
type
label
Mechanistic or mammalian targe ...... the cost of accelerated aging.
@ast
Mechanistic or mammalian targe ...... the cost of accelerated aging.
@en
prefLabel
Mechanistic or mammalian targe ...... the cost of accelerated aging.
@ast
Mechanistic or mammalian targe ...... the cost of accelerated aging.
@en
P2860
P356
P1433
P1476
Mechanistic or mammalian targe ...... the cost of accelerated aging.
@en
P2093
Geraldine M Paszkiewicz
Olga V Leontieva
P2860
P304
P356
10.18632/AGING.100528
P577
2012-12-01T00:00:00Z