Increased respiration in the sch9Delta mutant is required for increasing chronological life span but not replicative life span.
about
The TOR pathway comes of ageThe expanding role of yeast in cancer research and diagnosis: insights into the function of the oncosuppressors p53 and BRCA1/2Nutritional control of growth and development in yeastThe protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae.Down-regulating sphingolipid synthesis increases yeast lifespanExtension of chronological life span by reduced TOR signaling requires down-regulation of Sch9p and involves increased mitochondrial OXPHOS complex density.Effects of calorie restriction on life span of microorganisms.Ammonium is toxic for aging yeast cells, inducing death and shortening of the chronological lifespanFunctional and genetic interactions of TOR in the budding yeast Saccharomyces cerevisiae with myosin type II-deficiency (myo1Δ).TOR and ageing: a complex pathway for a complex process.L-carnosine affects the growth of Saccharomyces cerevisiae in a metabolism-dependent manner.Impact of nutrient imbalance on wine alcoholic fermentations: nitrogen excess enhances yeast cell death in lipid-limited must.Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling.Mitochondrial quality control during inheritance is associated with lifespan and mother-daughter age asymmetry in budding yeast.Mitochondrial genomic dysfunction causes dephosphorylation of Sch9 in the yeast Saccharomyces cerevisiae.The longevity of tor1Δ, sch9Δ, and ras2Δ mutants depends on actin dynamics in Saccharomyces cerevisiae.Interplay among Gcn5, Sch9 and mitochondria during chronological aging of wine yeast is dependent on growth conditions.Mitochondria and organismal longevity.The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availabilityReduced Histone Expression or a Defect in Chromatin Assembly Induces Respiration.Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan.A molecular mechanism of chronological aging in yeast.Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1.Living on the edge: stress and activation of stress responses promote lifespan extension.Posttranscriptional control of mitochondrial biogenesis: spatio-temporal regulation of the protein import process.Molecular mechanisms linking the evolutionary conserved TORC1-Sch9 nutrient signalling branch to lifespan regulation in Saccharomyces cerevisiae.The biochemistry and cell biology of aging: metabolic regulation through mitochondrial signaling.The role of mitochondria in mTOR-regulated longevity.Sphingolipids and mitochondrial function in budding yeast.Longevity pathways and maintenance of the proteome: the role of autophagy and mitophagy during yeast ageing.Dietary restriction and lifespan: Lessons from invertebrate models.Cell-autonomous mechanisms of chronological aging in the yeast Saccharomyces cerevisiaeLifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathwayLongevity of U cells of differentiated yeast colonies grown on respiratory medium depends on active glycolysis.Sch9 regulates intracellular protein ubiquitination by controlling stress responses.Mitochondrial dysfunction leads to reduced chronological lifespan and increased apoptosis in yeast.Increased heme synthesis in yeast induces a metabolic switch from fermentation to respiration even under conditions of glucose repression.Tor1, Sch9 and PKA downregulation in quiescence rely on Mtl1 to preserve mitochondrial integrity and cell survival.
P2860
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P2860
Increased respiration in the sch9Delta mutant is required for increasing chronological life span but not replicative life span.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Increased respiration in the s ...... but not replicative life span.
@en
type
label
Increased respiration in the s ...... but not replicative life span.
@en
prefLabel
Increased respiration in the s ...... but not replicative life span.
@en
P2860
P356
P1433
P1476
Increased respiration in the s ...... but not replicative life span.
@en
P2093
Hugo Lavoie
Malcolm Whiteway
P2860
P304
P356
10.1128/EC.00330-07
P577
2008-05-09T00:00:00Z