A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.
about
Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutationThreonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagyMitochondrial fission - a drug target for cytoprotection or cytodestruction?Autophagy, Innate Immunity and Tissue Repair in Acute Kidney InjuryMitochondria: A Therapeutic Target for Parkinson's Disease?Deconvoluting the complexity of autophagy and Parkinson's disease for potential therapeutic purposeAntioxidant responses and cellular adjustments to oxidative stressMitoconfusion: noncanonical functioning of dynamism factors in static mitochondria of the heartTitration of mitochondrial fusion rescues Mff-deficient cardiomyopathyMetabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress.Mitochondrial Quality Control in Cardiac DiseasesNew therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseasesDrp1 stabilizes p53 on the mitochondria to trigger necrosis under oxidative stress conditions in vitro and in vivoAcute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunctionDRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma.Inhibition of Drp1 hyper-activation is protective in animal models of experimental multiple sclerosis.Polymorphic regulation of mitochondrial fission and fusion modifies phenotypes of microglia in neuroinflammation.Increased mitochondrial fission and neuronal dysfunction in Huntington's disease: implications for molecular inhibitors of excessive mitochondrial fissionDynamin-related protein 1 as a therapeutic target in cardiac arrestMitochondrial dynamics in pulmonary arterial hypertension.Targeting GTPases in Parkinson's disease: comparison to the historic path of kinase drug discovery and perspectivesMdivi-1, mitochondrial fission inhibitor, impairs developmental competence and mitochondrial function of embryos and cells in pigs.The mechanoenzymatic core of dynamin-related protein 1 comprises the minimal machinery required for membrane constriction.Mitochondria: key players in the neurotoxic effects of amphetamines.Mitochondrial reactive oxygen species at the heart of the matter: new therapeutic approaches for cardiovascular diseases.Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation.Astaxanthin prevents pulmonary fibrosis by promoting myofibroblast apoptosis dependent on Drp1-mediated mitochondrial fission.Attenuation of Aβ toxicity by promotion of mitochondrial fusion in neuroblastoma cells by liquiritigenin.Exogenous expression of Drp1 plays neuroprotective roles in the Alzheimer's disease in the Aβ42 transgenic Drosophila model.Disabling mitochondrial reprogramming in cancerDynamin-related Protein 1 Oligomerization in Solution Impairs Functional Interactions with Membrane-anchored Mitochondrial Fission FactorNovel targets for mitochondrial medicine.Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stressUbisol-Q10 Prevents Glutamate-Induced Cell Death by Blocking Mitochondrial Fragmentation and Permeability Transition Pore OpeningVCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease.Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson's disease model induced by MPTPInhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration.Potential biomarkers to follow the progression and treatment response of Huntington's disease.Inhibitors of mitochondrial fission as a therapeutic strategy for diseases with oxidative stress and mitochondrial dysfunction.Development of pharmacological strategies for mitochondrial disorders.
P2860
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P2860
A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.
@en
type
label
A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.
@en
prefLabel
A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.
@en
P2093
P2860
P356
P1476
A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.
@en
P2093
P2860
P304
P356
10.1242/JCS.114439
P407
P577
2012-12-13T00:00:00Z