Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease. - Wikidata - awgldk - TriplyDB

Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease.

Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease.

http://www.wikidata.org/entity/Q36754811

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Chronic over-nutrition and dysregulation of GSK3 in diseases Lipid droplet-associated proteins in alcoholic liver disease: a potential linkage with hepatocellular damage Comparative gene identification-58/α/β hydrolase domain 5: more than just an adipose triglyceride lipase activator?Absence of perilipin 2 prevents hepatic steatosis, glucose intolerance and ceramide accumulation in alcohol-fed mice Enhanced atheroprotection and lesion remodelling by targeting the foam cell and increasing plasma cholesterol acceptors High-Fat Diet Causes Subfertility and Compromised Ovarian Function Independent of Obesity in Mice.PHEX mimetic (SPR4-peptide) corrects and improves HYP and wild type mice energy-metabolism Ontogeny of hepatic energy metabolism genes in mice as revealed by RNA-sequencing PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle.A systems biology approach utilizing a mouse diversity panel identifies genetic differences influencing isoniazid-induced microvesicular steatosis.Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice Plin2 inhibits cellular glucose uptake through interactions with SNAP23, a SNARE complex protein The interplay of protein kinase A and perilipin 5 regulates cardiac lipolysis.Perilipin-2 Modulates Lipid Absorption and Microbiome Responses in the Mouse Intestine.The Lipid Droplet Protein Hypoxia-inducible Gene 2 Promotes Hepatic Triglyceride Deposition by Inhibiting Lipolysis Perilipins: lipid droplet coat proteins adapted for tissue-specific energy storage and utilization, and lipid cytoprotection Perilipin 5, a lipid droplet protein adapted to mitochondrial energy utilization.Liver Perilipin 5 Expression Worsens Hepatosteatosis But Not Insulin Resistance in High Fat-Fed Mice.IL-25 or IL-17E Protects against High-Fat Diet-Induced Hepatic Steatosis in Mice Dependent upon IL-13 Activation of STAT6.Pathophysiology of lipid droplet proteins in liver diseases.Perilipin2 plays a positive role in adipocytes during lipolysis by escaping proteasomal degradation.Liver-specific loss of Perilipin 2 alleviates diet-induced hepatic steatosis, inflammation, and fibrosis.Dynamic regulation of hepatic lipid droplet properties by diet Proteomic profiling of cellular steatosis with concomitant oxidative stress in vitro Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance.Modulation of adipose tissue lipolysis and body weight by high-density lipoproteins in mice.Lipoprotein lipase activity is required for cardiac lipid droplet production.Lipid Use and Misuse by the Heart.Lipid droplet metabolism Inositol hexakisphosphate kinase-1 interacts with perilipin1 to modulate lipolysis.Perilipins: a diversity of intracellular lipid droplet proteins.Perilipin-2 modulates dietary fat-induced microbial global gene expression profiles in the mouse intestine.An Overview of Lipid Droplets in Cancer and Cancer Stem Cells.Modeling Nonalcoholic Fatty Liver Disease with Human Pluripotent Stem Cell-Derived Immature Hepatocyte-Like Cells Reveals Activation of PLIN2 and Confirms Regulatory Functions of Peroxisome Proliferator-Activated Receptor Alpha.Development of hypertrophic cardiomyopathy in perilipin-1 null mice with adipose tissue dysfunction.In vivo analysis at the cellular level reveals similar steatosis induction in both hepatitis C virus genotype 1 and 3 infections.Cardiac overexpression of perilipin 2 induces dynamic steatosis: prevention by hormone-sensitive lipase.Perilipin-2 Deletion Impairs Hepatic Lipid Accumulation by Interfering with Sterol Regulatory Element-binding Protein (SREBP) Activation and Altering the Hepatic Lipidome.Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation.A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis.

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Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease.

http://www.wikidata.org/entity/Q36754811

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2013 nî lūn-bûn

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Perilipin-2-null mice are prot ...... tion, and fatty liver disease.

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Journal of Lipid Research

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Perilipin-2-null mice are prot ...... tion, and fatty liver disease.

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Amanda E Crunk

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Andrew S Greenberg

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Ayla Mansur

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Christine E Graham

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David J Orlicky

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Elise S Bales

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James L McManaman

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Matthew Jackman

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Shannon Cain

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P2860

The Obesity Epidemic

Obesity is associated with macrophage accumulation in adipose tissue

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis

Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein

PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver

Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity

Perilipin 5, a lipid droplet-binding protein, protects heart from oxidative burden by sequestering fatty acid from excessive oxidation

OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization

The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria

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1346-1359

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10.1194/JLR.M035063

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5

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54

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Thomas A Bowman

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2013-02-12T00:00:00Z

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23402988

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