Cell selective conditional null mutations of serine racemase demonstrate a predominate localization in cortical glutamatergic neurons - Wikidata - awgldk - TriplyDB

Cell selective conditional null mutations of serine racemase demonstrate a predominate localization in cortical glutamatergic neurons

Cell selective conditional null mutations of serine racemase demonstrate a predominate localization in cortical glutamatergic neurons

http://www.wikidata.org/entity/Q36755574

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Time and space profiling of NMDA receptor co-agonist functions Nucleus basalis-enabled stimulus-specific plasticity in the visual cortex is mediated by astrocytes.Cell-type specific mechanisms of D-serine uptake and release in the brain Heterogeneity of D-Serine Distribution in the Human Central Nervous System.The NMDA Receptor and Schizophrenia: From Pathophysiology to Treatment.The postnatal development of D-serine in the retinas of two mouse strains, including a mutant mouse with a deficiency in D-amino acid oxidase and a serine racemase knockout mouse The NMDA receptor 'glycine modulatory site' in schizophrenia: D-serine, glycine, and beyond.Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior Global biochemical profiling identifies β-hydroxypyruvate as a potential mediator of type 2 diabetes in mice and humans.Glycolytic flux controls D-serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes.D-serine and serine racemase are localized to neurons in the adult mouse and human forebrain D-serine uptake and release in PC-12 cells measured by chiral microchip electrophoresis-mass spectrometry.D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures Neuronal D-serine regulates dendritic architecture in the somatosensory cortex Multifaceted roles for astrocytes in spreading depolarization: A target for limiting spreading depolarization in acute brain injury?Roles of Presynaptic NMDA Receptors in Neurotransmission and Plasticity D-Serine and Serine Racemase Are Associated with PSD-95 and Glutamatergic Synapse Stability.Neuronal serine racemase regulates extracellular D-serine levels in the adult mouse hippocampus.D-serine as a gliotransmitter and its roles in brain development and disease.Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level D-serine in glia and neurons derives from 3-phosphoglycerate dehydrogenase.D-serine in the midbrain periaqueductal gray contributes to morphine tolerance in rats.Calcium Signaling and Gliotransmission in Normal vs. Reactive Astrocytes.Serine racemase: an unconventional enzyme for an unconventional transmitter.D-Amino acids in brain neurotransmission and synaptic plasticity.D-Amino acids in the brain and mutant rodents lacking D-amino-acid oxidase activity.Serine racemase as a prime target for age-related memory deficits.Molecular approaches for manipulating astrocytic signaling in vivo.Perisynaptic astroglial processes: dynamic processors of neuronal information.FBXO22 protein is required for optimal synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine.The Rise and Fall of the d-Serine-Mediated Gliotransmission Hypothesis.D-Amino Acids in the Nervous and Endocrine Systems.Astrocytes and synaptic plasticity in health and disease.Asc-1 Transporter Regulation of Synaptic Activity via the Tonic Release of d-Serine in the Forebrain.Evidence for Tonic Control by the GABAA Receptor of Extracellular D-Serine Concentrations in the Medial Prefrontal Cortex of Rodents.Nuclear Compartmentalization of Serine Racemase Regulates D-Serine Production: IMPLICATIONS FOR N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ACTIVATION.D-serine released by astrocytes in brainstem regulates breathing response to CO2 levels Enhanced astrocytic d-serine underlies synaptic damage after traumatic brain injury.ATP binding to human serine racemase is cooperative and modulated by glycine.Multiple Lines of Evidence Indicate That Gliotransmission Does Not Occur under Physiological Conditions.

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P2860

Cell selective conditional null mutations of serine racemase demonstrate a predominate localization in cortical glutamatergic neurons

http://www.wikidata.org/entity/Q36755574

description

2012 nî lūn-bûn

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name

Cell selective conditional nul ...... cortical glutamatergic neurons

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Cell selective conditional nul ...... cortical glutamatergic neurons

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type

label

Cell selective conditional nul ...... cortical glutamatergic neurons

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Cell selective conditional nul ...... cortical glutamatergic neurons

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prefLabel

Cell selective conditional nul ...... cortical glutamatergic neurons

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Cell selective conditional nul ...... cortical glutamatergic neurons

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Cellular and Molecular Neurobiology

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Cell selective conditional nul ...... cortical glutamatergic neurons

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P2093

Alo C Basu

http://www.w3.org/2001/XMLSchema#string

Joseph T Coyle

http://www.w3.org/2001/XMLSchema#string

Michael A Benneyworth

http://www.w3.org/2001/XMLSchema#string

Vadim Y Bolshakov

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Yan Li

http://www.w3.org/2001/XMLSchema#string

P2860

D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor

Short-term synaptic plasticity

Glia-derived D-serine controls NMDA receptor activity and synaptic memory

Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity

Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission

Spatiotemporal asymmetry of associative synaptic plasticity in fear conditioning pathways.

Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior

Long-term potentiation depends on release of D-serine from astrocytes.

Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D-serine

Neuron-derived D-serine release provides a novel means to activate N-methyl-D-aspartate receptors.

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10.1007/S10571-012-9808-4

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4

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32

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