Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors
about
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulatorInvestigation of allosteric modulation mechanism of metabotropic glutamate receptor 1 by molecular dynamics simulations, free energy and weak interaction analysisTaste substance binding elicits conformational change of taste receptor T1r heterodimer extracellular domainsDeterminants of endogenous ligand specificity divergence among metabotropic glutamate receptorsConformational dynamics of a class C G-protein-coupled receptorSensing conformational changes in metabotropic glutamate receptors.Orthogonal Optical Control of a G Protein-Coupled Receptor with a SNAP-Tethered Photochromic Ligand.Estimation of ligand efficacies of metabotropic glutamate receptors from conformational forces obtained from molecular dynamics simulations.Structure and function of G protein-coupled receptor oligomers: implications for drug discovery.Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer.Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells.Organization and functions of mGlu and GABAB receptor complexes.Differential modulation of the lactisole 'Sweet Water Taste' by sweeteners.Biased AllosteryMajor ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer.Activation mechanism of the G protein-coupled sweet receptor heterodimer with sweeteners and allosteric agonists.Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors.Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer.mGluR5: exploration of orthosteric and allosteric ligand binding pockets and their applications to drug discovery.Class C G protein-coupled receptors: reviving old couples with new partners.Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation.Structural biology of GABAB receptor.HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.Direct coupling of detergent purified human mGlu5 receptor to the heterotrimeric G proteins Gq and Gs.Oligomerization of a G protein-coupled receptor in neurons controlled by its structural dynamics.Fine tuning of sub-millisecond conformational dynamics controls metabotropic glutamate receptors agonist efficacy
P2860
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P2860
Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Illuminating the activation me ...... tabotropic glutamate receptors
@ast
Illuminating the activation me ...... tabotropic glutamate receptors
@en
type
label
Illuminating the activation me ...... tabotropic glutamate receptors
@ast
Illuminating the activation me ...... tabotropic glutamate receptors
@en
prefLabel
Illuminating the activation me ...... tabotropic glutamate receptors
@ast
Illuminating the activation me ...... tabotropic glutamate receptors
@en
P2093
P2860
P50
P356
P1476
Illuminating the activation me ...... tabotropic glutamate receptors
@en
P2093
Eric Trinquet
Etienne Doumazane
Ludovic Fabre
Pauline Scholler
P2860
P304
P356
10.1073/PNAS.1215615110
P407
P577
2013-03-04T00:00:00Z