Aging by epigenetics--a consequence of chromatin damage? - Wikidata - awgldk - TriplyDB

Aging by epigenetics--a consequence of chromatin damage?

Aging by epigenetics--a consequence of chromatin damage?

http://www.wikidata.org/entity/Q36766079

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Genome-environment interactions that modulate aging: powerful targets for drug discovery Epigenetics and aging The role of DNA methylation in aging, rejuvenation, and age-related disease Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis Loss of ATRX does not confer susceptibility to osteoarthritis Tissue- and age-dependent expression of RNA-binding proteins that influence mRNA turnover and translation Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories.Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in A Fine-Tune Role of Mir-125a-5p on Foxn1 During Age-Associated Changes in the Thymus.An epigenetic hypothesis of aging-related cognitive dysfunction A role for SUV39H1-mediated H3K9 trimethylation in the control of genome stability and senescence in WI38 human diploid lung fibroblasts WI-38 senescence is associated with global and site-specific hypomethylation.Chromatin remodeling in the aging genome of Drosophila.Stem cells and aging: a chicken-or-the-egg issue?Epigenetics across the human lifespan.Epigenetic changes play critical role in age-associated dysfunctions of the liver.Age-associated increase in heterochromatic marks in murine and primate tissues.Manifestations and mechanisms of stem cell aging.Asthma in the elderly: Current understanding and future research needs--a report of a National Institute on Aging (NIA) workshop.Disease- and age-related changes in histone acetylation at gene promoters in psychiatric disorders.A Mutation in Plant-Specific SWI2/SNF2-Like Chromatin-Remodeling Proteins, DRD1 and DDM1, Delays Leaf Senescence in Arabidopsis thaliana.Basic concepts of epigenetics: impact of environmental signals on gene expression.Global heterochromatin loss: a unifying theory of aging?Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome.H3K9me3 Inhibition Improves Memory, Promotes Spine Formation, and Increases BDNF Levels in the Aged Hippocampus.Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements.Aging-dependent upregulation of IL-23p19 gene expression in dendritic cells is associated with differential transcription factor binding and histone modifications.Effects of hyperglycemia and aging on nuclear sirtuins and DNA damage of mouse hepatocytes High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri: a new vertebrate model for aging research.Epigenetic changes in gliomas.Epigenetic modifications in rheumatoid arthritis.Doxycycline, metronidazole and isotretinoin: Do they modify microRNA/mRNA expression profiles and function in murine T-cells?Nuclear functions of the HMG proteins.The role of CUGBP1 in age-dependent changes of liver functions.The great unravelling: chromatin as a modulator of the aging process.Senescence bypass in mesenchymal stem cells: a potential pathogenesis and implications of pro-senescence therapy in sarcomas.Causes and Consequences of Age-Related Changes in DNA Methylation: A Role for ROS?The emerging role of senescent cells in tissue homeostasis and pathophysiology.Histone modifications contribute to cellular replicative and hydrogen peroxide-induced premature senescence in human embryonic lung fibroblasts.Heterochromatin marks HP1γ, HP1α and H3K9me3, and DNA damage response activation in human testis development and germ cell tumours.

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Aging by epigenetics--a consequence of chromatin damage?

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Aging by epigenetics--a consequence of chromatin damage?

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J.YEXCR.2008.02.023

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Experimental Cell Research

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Aging by epigenetics--a consequence of chromatin damage?

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Gowrishankar Banumathy

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Peter D Adams

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P2860

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

Crystal structure of the nucleosome core particle at 2.8 A resolution

PRAK is essential for ras-induced senescence and tumor suppression

Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis

A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1

Epigenetic differences arise during the lifetime of monozygotic twins

Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

DNA methylation profiling of human chromosomes 6, 20 and 22

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

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1909-1917

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