Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice
about
Methylphenidate enhances NMDA-receptor response in medial prefrontal cortex via sigma-1 receptor: a novel mechanism for methylphenidate actionSigma receptors: potential targets for a new class of antidepressant drugThe Antinociceptive Effect of Sigma-1 Receptor Antagonist, BD1047, in a Capsaicin Induced Headache Model in RatsRegulation of AMPA receptors in spinal nociception.Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization.Operant self-administration of a sigma ligand improves nociceptive and emotional manifestations of neuropathic pain.Sigma-1 Receptor Antagonist BD1047 Reduces Allodynia and Spinal ERK Phosphorylation Following Chronic Compression of Dorsal Root Ganglion in RatsSigma-1 receptors and animal studies centered on pain and analgesia.Sigma-1 receptor enhances neurite elongation of cerebellar granule neurons via TrkB signalingSpinal neuronal NOS activation mediates sigma-1 receptor-induced mechanical and thermal hypersensitivity in mice: involvement of PKC-dependent GluN1 phosphorylationSigma-1 receptor mediates acquisition of alcohol drinking and seeking behavior in alcohol-preferring rats.Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats.Central nociceptive sensitization vs. spinal cord training: opposing forms of plasticity that dictate function after complete spinal cord injuryThe sigma-1 receptor: roles in neuronal plasticity and diseaseSigma receptors [σRs]: biology in normal and diseased statesAntagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors.Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABA receptors.The pharmacology of sigma-1 receptors.Antinociceptive Profile of Levo-tetrahydropalmatine in Acute and Chronic Pain Mice Models: Role of spinal sigma-1 receptor.A critical role of spinal Shank2 proteins in NMDA-induced pain hypersensitivity.Dehydroepiandrosterone sulphate: action and mechanism in the brain.Potential role of nitric oxide synthase isoforms in pathophysiology of neuropathic pain.Investigational sigma-1 receptor antagonists for the treatment of pain.Pharmacological Modulation of the Sigma 1 Receptor and the Treatment of Pain.Visualizing Nerve Injury in a Neuropathic Pain Model with [18F]FTC-146 PET/MRI.The dipeptide Phe-Phe amide attenuates signs of hyperalgesia, allodynia and nociception in diabetic mice using a mechanism involving the sigma receptor system.Sigma-1 and N-Methyl-d-Aspartate Receptors: A Partnership with Beneficial Outcomes.Sigma receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates neuronal nitric oxide synthase/postsynaptic density-95 coupling mechanisms and protects against neonatal ischemic degeneration of striatal neurons.The σ1 receptor engages the redox-regulated HINT1 protein to bring opioid analgesia under NMDA receptor negative control.Sigma-1 Receptor and Neuronal Excitability.Prepubertal castration-associated developmental changes in sigma-1 receptor gene expression levels regulate hippocampus area CA1 activity during adolescence.Na(+)/K(+)-ATPase inhibition upregulates NMDA-evoked currents in rat hippocampal CA1 pyramidal neurons.NR2B phosphorylation at tyrosine 1472 in spinal dorsal horn contributed to N-methyl-D-aspartate-induced pain hypersensitivity in mice.Critical role of sigma-1 receptors in central neuropathic pain-related behaviours after mild spinal cord injury in mice.Sigma-1 Receptor and Pain.The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation.Neurosteroids in Pain Management: A New Perspective on an Old Player
P2860
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P2860
Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Activation of the spinal sigma ...... ion of the NR1 subunit in mice
@ast
Activation of the spinal sigma ...... ion of the NR1 subunit in mice
@en
type
label
Activation of the spinal sigma ...... ion of the NR1 subunit in mice
@ast
Activation of the spinal sigma ...... ion of the NR1 subunit in mice
@en
prefLabel
Activation of the spinal sigma ...... ion of the NR1 subunit in mice
@ast
Activation of the spinal sigma ...... ion of the NR1 subunit in mice
@en
P2093
P2860
P50
P356
P1476
Activation of the spinal sigma ...... ion of the NR1 subunit in mice
@en
P2093
P2860
P304
P356
10.1038/BJP.2008.159
P407
P577
2008-05-19T00:00:00Z