Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. - Wikidata - awgldk - TriplyDB

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.

http://www.wikidata.org/entity/Q36777971

about

Explaining oscillations and variability in the p53-Mdm2 system Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation Protein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cells ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress USP10 regulates p53 localization and stability by deubiquitinating p53 The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1 Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites Immunoglobulin class switch recombination is impaired in Atm-deficient mice The combined status of ATM and p53 link tumor development with therapeutic response p53 in rheumatoid arthritis: friend or foe?Regulation of Mutant p53 Protein Expression Transcriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, inducible responses and genotoxic adaptation Antioxidative dietary compounds modulate gene expression associated with apoptosis, DNA repair, inhibition of cell proliferation and migration Dysregulation of ubiquitin ligases in cancer Multiple sites of in vivo phosphorylation in the MDM2 oncoprotein cluster within two important functional domains MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts Pathways governing G1/S transition and their response to DNA damage Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes Hdmx modulates the outcome of p53 activation in human tumor cells Phosphorylation of murine double minute clone 2 (MDM2) protein at serine-267 by protein kinase CK2 in vitro and in cultured cells ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage Activation and activities of the p53 tumour suppressor protein The ubiquitin-proteasome pathway and proteasome inhibitors A Physical Mechanism and Global Quantification of Breast Cancer Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer.Comprehensive analysis of the ATM, CHEK2 and ERBB2 genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study.Udu deficiency activates DNA damage checkpoint.A novel mouse model for ataxia-telangiectasia with a N-terminal mutation displays a behavioral defect and a low incidence of lymphoma but no increased oxidative burden.Utilization of oriented peptide libraries to identify substrate motifs selected by ATM.Downregulation of MDM2 stabilizes p53 by inhibiting p53 ubiquitination in response to specific alkylating agents.ATM activates p53 by regulating MDM2 oligomerization and E3 processivity Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation.SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization The thyroid hormone receptor-alpha (TRalpha) gene encoding TRalpha1 controls deoxyribonucleic acid damage-induced tissue repair.Protein degradation rate is the dominant mechanism accounting for the differences in protein abundance of basal p53 in a human breast and colorectal cancer cell line

P2860

Q21202791-EA7F9511-2602-452D-B3EA-FBA4992E2DF3 Q22254665-2D2C5543-0C12-4643-9B9A-4739F500DDF4 Q24291244-FD3803F5-D258-4771-93C1-FEDF3AA8CF5B Q24291894-FFD9094D-3530-4AEA-B0D5-7591F1E55BDB Q24296257-62B364E3-7152-491C-A71A-31B5B0CC2947 Q24296967-192720AB-1215-4FA8-A24F-EF41AD30548E Q24323508-70B8F850-5E55-4D69-A8FB-64CFD2EC37C0 Q24338320-23DE0BB0-4229-4413-8971-E820CA849CCE Q24534983-DD229619-3A37-4888-BECA-398BBD3108BC Q24550952-55EB0B94-7800-4474-A57B-DB6CAC21D337 Q24597483-09CAB4C4-009D-490D-BE56-CA8FA66BCDE7 Q24610054-2E690BAE-5AEE-4492-B3D8-9ACFFB4F490C Q24647660-E1DA4AF1-8388-462B-821F-8FFA0F90B8ED Q24652535-B84C0660-0E54-4CF1-9416-BE6E58AF05C3 Q24806906-0A121080-AED4-4BFD-B661-1452A3F20698 Q26770579-5BA70125-A2F0-4ED0-A788-8120CD07F51E Q27026117-77E92F72-47B5-4630-A732-95E7F8BC8C1A Q27027482-982651DD-6052-4904-B955-0792701925FF Q28086796-AEF7957E-C1BB-4555-8BC2-7DA6E00E8EFA Q28142503-D670420A-EE13-4521-A7A8-3C0E11CB5B13 Q28200748-521B58D5-2962-43A0-98B3-E2F29F2951D3 Q28202348-2D938315-025E-41D1-8106-195FCB6C7104 Q28210085-A4FA18D5-AF26-48BD-B7AE-F1DF6C3FBF7E Q28257444-242F652C-D095-4D21-A27A-45840A25B0D2 Q28361800-E74E3039-996F-4071-A257-777F80A47A1F Q28364113-39C4D233-8A5F-49E3-9735-56152A3D4F2D Q28366563-2466308F-8266-4C6A-97BC-04062FCC5391 Q28367002-5C8727BF-26F0-46F3-BC06-9D9EC3F5E016 Q28596313-1A1DAAF7-C5EE-4132-8EFA-EA48D5D2E505 Q30374671-36FCBDA5-0CC9-4B78-8C3D-35211276ABD9 Q30478981-19A407AD-FA73-443D-8119-8C3ED684FBAA Q30490662-ABC1A826-3DA9-443C-8E50-EC74130DB8CD Q30806557-0B2D16A3-F297-4C6C-8083-1FD2633AF967 Q30868748-C3C692FE-6442-4BA4-A6D9-F10EA23DF265 Q32062474-61FFEA53-C7DE-42A8-9FB1-4511CC7AABB0 Q33552958-42D79F0E-4D46-4619-9B08-E268D5B7AA36 Q33558779-FFCC15DD-22EA-410D-B2C0-88B663EF9A8F Q33640598-E8EE08C9-EAA7-4FB1-B631-863D84C30533 Q33643286-67ABA424-4EB2-476E-BED4-9341B8645E76 Q33657982-46CC3A3E-A869-4642-8604-A3C458257268

P2860

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.

http://www.wikidata.org/entity/Q36777971

description

1999 nî lūn-bûn

@nan

1999年の論文

@ja

1999年論文

@yue

1999年論文

@zh-hant

1999年論文

@zh-hk

1999年論文

@zh-mo

1999年論文

@zh-tw

1999年论文

@wuu

1999年论文

@zh

1999年论文

@zh-cn

name

Rapid ATM-dependent phosphoryl ...... ion in response to DNA damage.

@ast

Rapid ATM-dependent phosphoryl ...... ion in response to DNA damage.

@en

type

label

Rapid ATM-dependent phosphoryl ...... ion in response to DNA damage.

@ast

Rapid ATM-dependent phosphoryl ...... ion in response to DNA damage.

@en

prefLabel

Rapid ATM-dependent phosphoryl ...... ion in response to DNA damage.

@ast

Rapid ATM-dependent phosphoryl ...... ion in response to DNA damage.

@en

P1433

Q36777971-C2F609CC-0B3D-4FF5-A4F6-A0AA2C077660

P1476

Q36777971-5640AD18-C58D-4BA7-B386-CBB14FC6401A

P2093

Q36777971-1660FBC2-31F7-4366-A509-E8D474617187

Q36777971-5931B2BE-20F6-4309-8D4C-9DE2C918FC98

Q36777971-B4708A25-1675-4D20-B906-C628E0E717A2

Q36777971-C0F851BD-F2E7-43E0-AF15-F1CED8E61F94

Q36777971-CCE2D468-4B58-4A21-AE35-67269A1727B7

Q36777971-DA96DAAE-FD45-4730-878F-130B3E0FB6F8

P2860

Q36777971-0C3FED7E-7560-4070-9AF3-3047011B0315

Q36777971-11666C15-5204-4307-8B93-56DA6FDBB475

Q36777971-118BA7F4-54E0-4749-BDAC-009496724E6B

Q36777971-1286D74B-AE57-406D-8A76-445F68A46F3F

Q36777971-14D9C7AD-8623-4076-86D0-5DE960BED6B1

Q36777971-1F2FC4C6-90AC-49ED-AAF6-73540C9BEC14

Q36777971-213E82C2-A135-45A1-979A-1F2395BE347C

Q36777971-27B13CE3-35FB-428D-ABF3-CB8AF8681176

Q36777971-29BA9AFB-89CD-4686-99AA-A3BA09C226CB

Q36777971-2C139CCB-6139-491F-87EE-99C72346132B

P304

Q36777971-80ABF9ED-2072-45F2-AB05-E73848D9B412

P31

Q36777971-D388D8D2-BD71-4B92-8803-88BB274C1AF2

P356

Q36777971-02D42899-892B-4049-8A4F-E0E521B824D2

P407

Q36777971-835AE8E7-7569-4868-B7DD-BAE4AFAA3B58

P433

Q36777971-BDC7DE79-3E96-4663-9D7B-F166C6E4204D

P478

Q36777971-D1FB5997-0501-4218-AC2B-DF38E879A43A

P577

Q36777971-91CA6A0B-B4BE-484C-B74F-97EBCB5F8712

P5875

Q36777971-4B140E11-5628-4633-BFCD-3216860E3ED1

P698

Q36777971-971B2D19-283F-4D40-931A-D74782FD8573

P921

Q36777971-51381CA2-933E-4375-8856-9926BBF820C8

Q36777971-BB8D4FC5-B2CF-41A4-992F-27D22886B062

P932

Q36777971-B49B786E-3E5D-43A9-BEE3-DC807BD3B0A3

P356

PNAS.96.26.14973

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Rapid ATM-dependent phosphoryl ...... ion in response to DNA damage.

@en

P2093

D Shkedy

http://www.w3.org/2001/XMLSchema#string

M Oren

http://www.w3.org/2001/XMLSchema#string

R Khosravi

http://www.w3.org/2001/XMLSchema#string

R Maya

http://www.w3.org/2001/XMLSchema#string

T Gottlieb

http://www.w3.org/2001/XMLSchema#string

Y Shiloh

http://www.w3.org/2001/XMLSchema#string

P2860

A role for ATR in the DNA damage-induced phosphorylation of p53

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

Mdm2 promotes the rapid degradation of p53

Regulation of p53 function and stability by phosphorylation

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

Regulation of p53 stability by Mdm2

p53, the cellular gatekeeper for growth and division

Functions of the MDM2 oncoprotein

Beta3A-adaptin, a subunit of the adaptor-like complex AP-3

P304

14973-14977

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.96.26.14973

http://www.w3.org/2001/XMLSchema#string

P407

P433

26

http://www.w3.org/2001/XMLSchema#string

P478

96

http://www.w3.org/2001/XMLSchema#string

P577

1999-12-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51357214

http://www.w3.org/2001/XMLSchema#string

P698

10611322

http://www.w3.org/2001/XMLSchema#string

P921

phosphorylation

P932

24757

http://www.w3.org/2001/XMLSchema#string