Mutations in the Jun delta region suggest an inverse correlation between transformation and transcriptional activation.
about
Targeted disruption of the c-fos gene demonstrates c-fos-dependent and -independent pathways for gene expression stimulated by growth factors or oncogenesDistinct roles of Jun : Fos and Jun : ATF dimers in oncogenesisAP-1 in cell proliferation and survivalIdentification and characterization of genes upregulated in cells transformed by v-Jun.Specific activation in jun-transformed avian fibroblasts of a gene (bkj) related to the avian beta-keratin gene familyTranscription factor ATF2 cooperates with v-Jun to promote growth factor-independent proliferation in vitro and tumor formation in vivoAP-1 factors play an important role in transformation induced by the v-rel oncogene.Transactivation of gene expression by Myc is inhibited by mutation at the phosphorylation sites Thr-58 and Ser-62.The transcription factor AP-1 is required for EGF-induced activation of rho-like GTPases, cytoskeletal rearrangements, motility, and in vitro invasion of A431 cells.Heparin-binding epidermal growth factor-like growth factor, a v-Jun target gene, induces oncogenic transformation.A Jun-binding protein related to a putative tumor suppressorIdentification of downstream-initiated c-Myc proteins which are dominant-negative inhibitors of transactivation by full-length c-Myc proteins.JunD mutants with spontaneously acquired transforming potential have enhanced transactivating activity in combination with Fra-2Hormone-regulatable neoplastic transformation induced by a Jun-estrogen receptor chimeraNuclear translocation of viral Jun but not of cellular Jun is cell cycle dependent.The 2 Faces of JNK Signaling in Cancer.Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A proteinOncogenic effect of delta deletion in v-Jun does not result from uncoupling Jun from JNK signaling.Transformation by the fos or jun oncogene does not increase AP-1 DNA-binding activity.Ras-dependent signal transduction is indispensable but not sufficient for the activation of AP1/Jun by PKC delta.Proliferative activation of quiescent Rat-1A cells by delta FosB.Microarray analysis identifies Autotaxin, a tumour cell motility and angiogenic factor with lysophospholipase D activity, as a specific target of cell transformation by v-Jun.Artificial oncoproteins: modified versions of the yeast bZip protein GCN4 induce cellular transformation.The c-Jun delta-domain inhibits neuroendocrine promoter activity in a DNA sequence- and pituitary-specific manner.
P2860
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P2860
Mutations in the Jun delta region suggest an inverse correlation between transformation and transcriptional activation.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Mutations in the Jun delta reg ...... nd transcriptional activation.
@ast
Mutations in the Jun delta reg ...... nd transcriptional activation.
@en
type
label
Mutations in the Jun delta reg ...... nd transcriptional activation.
@ast
Mutations in the Jun delta reg ...... nd transcriptional activation.
@en
prefLabel
Mutations in the Jun delta reg ...... nd transcriptional activation.
@ast
Mutations in the Jun delta reg ...... nd transcriptional activation.
@en
P2093
P2860
P356
P1476
Mutations in the Jun delta reg ...... nd transcriptional activation.
@en
P2093
I M Morgan
L S Håvarstein
P2860
P304
P356
10.1073/PNAS.89.2.618
P407
P577
1992-01-01T00:00:00Z