Redesign of a cross-reactive antibody to dengue virus with broad-spectrum activity and increased in vivo potency.
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Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant EpitopeDengue: an update on treatment optionsAdvances in Antibody DesignA broadly neutralizing human monoclonal antibody is effective against H7N9.Inferring the microscopic surface energy of protein-protein interfaces from mutation data.Identification and characterization of a neutralizing monoclonal antibody that provides complete protection against Yersinia pestis.Temperature-dependent folding allows stable dimerization of secretory and virus-associated E proteins of Dengue and Zika viruses in mammalian cells.Comprehensive mapping of functional epitopes on dengue virus glycoprotein E DIII for binding to broadly neutralizing antibodies 4E11 and 4E5A by phage display.Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swapping.Protein engineering strategies for the development of viral vaccines and immunotherapeutics.Therapeutic antibodies as a treatment option for dengue fever.Discovery of protective B-cell epitopes for development of antimicrobial vaccines and antibody therapeutics.A potent neutralizing antibody with therapeutic potential against all four serotypes of dengue virus.Development of Antibody Therapeutics against Flaviviruses.Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs.Rational Engineering and Characterization of an mAb that Neutralizes Zika Virus by Targeting a Mutationally Constrained Quaternary Epitope.Computational Modeling of Hepatitis C Virus Envelope Glycoprotein Structure and Recognition.Molecular basis for dengue virus broad cross-neutralization by humanized monoclonal antibody 513.DisruPPI: structure-based computational redesign algorithm for protein binding disruption.Engineered Dengue Virus Domain III Proteins Elicit Cross-Neutralizing Antibody Responses in Mice
P2860
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P2860
Redesign of a cross-reactive antibody to dengue virus with broad-spectrum activity and increased in vivo potency.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Redesign of a cross-reactive a ...... and increased in vivo potency.
@en
type
label
Redesign of a cross-reactive a ...... and increased in vivo potency.
@en
prefLabel
Redesign of a cross-reactive a ...... and increased in vivo potency.
@en
P2093
P2860
P356
P1476
Redesign of a cross-reactive a ...... and increased in vivo potency.
@en
P2093
Andrew Hatas
Gerald N Wogan
Kannan Tharakaraman
Luke N Robinson
Ram Sasisekharan
V Sasisekharan
Yi-Ling Chen
P2860
P304
P356
10.1073/PNAS.1303645110
P407
P577
2013-04-08T00:00:00Z