Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model. - Wikidata - awgldk - TriplyDB

Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model.

Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model.

http://www.wikidata.org/entity/Q36799810

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Neural stem/progenitor cells in Alzheimer's disease Microglial Priming and Alzheimer's Disease: A Possible Role for (Early) Immune Challenges and Epigenetics?Targeting innate immunity for neurodegenerative disorders of the central nervous system Fundamental role of pan-inflammation and oxidative-nitrosative pathways in neuropathogenesis of Alzheimer's disease in focal cerebral ischemic rats Fundamental role of pan-inflammation and oxidative-nitrosative pathways in neuropathogenesis of Alzheimer's disease The dual roles of cytokines in Alzheimer's disease: update on interleukins, TNF-α, TGF-β and IFN-γ Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease Rodent models of neuroinflammation for Alzheimer's disease Neuroinflammation in Alzheimer's disease Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain.Neuroinflammation in Alzheimer's disease Selective Brain-Targeted Antagonism of p38 MAPKα Reduces Hippocampal IL-1β Levels and Improves Morris Water Maze Performance in Aged Rats Chronic traumatic encephalopathy: clinical-biomarker correlations and current concepts in pathogenesis.Autoimmune manifestations in the 3xTg-AD model of Alzheimer's disease.R-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer's disease.Glial contributions to neurodegeneration in tauopathies.Reduced cerebrospinal fluid concentration of interleukin-12/23 subunit p40 in patients with cognitive impairment.Neuroprotective Effect of Fagopyrum dibotrys Extract against Alzheimer's Disease Magnesium ion influx reduces neuroinflammation in Aβ precursor protein/Presenilin 1 transgenic mice by suppressing the expression of interleukin-1β.DNA-PK and P38 MAPK: A Kinase Collusion in Alzheimer's Disease?Interleukin-1β mediated amyloid plaque clearance is independent of CCR2 signaling in the APP/PS1 mouse model of Alzheimer's disease.Opposing effects of membrane-anchored CX3CL1 on amyloid and tau pathologies via the p38 MAPK pathway Amyloid β and Tau Alzheimer's disease related pathology is reduced by Toll-like receptor 9 stimulation.Inflammasomes as therapeutic targets for Alzheimer's disease.Neuregulin1-β decreases IL-1β-induced neutrophil adhesion to human brain microvascular endothelial cells Models of β-amyloid induced Tau-pathology: the long and "folded" road to understand the mechanism.Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation.Ccr2 deletion dissociates cavity size and tau pathology after mild traumatic brain injury GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP.Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1.Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A.The blockage of the Nogo/NgR signal pathway in microglia alleviates the formation of Aβ plaques and tau phosphorylation in APP/PS1 transgenic mice.High Resolution Dissection of Reactive Glial Nets in Alzheimer's Disease.Acute and subacute IL-1β administrations differentially modulate neuroimmune and neurotrophic systems: possible implications for neuroprotection and neurodegeneration Differential effects of duration and age on the consequences of neuroinflammation in the hippocampus Neuregulin1-β decreases interleukin-1β-induced RhoA activation, myosin light chain phosphorylation, and endothelial hyperpermeability.Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy.Oligomeric amyloid β induces IL-1β processing via production of ROS: implication in Alzheimer's disease.Involvement of interleukin-1β in the autophagic process of microglia: relevance to Alzheimer's disease

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Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model.

http://www.wikidata.org/entity/Q36799810

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Sustained interleukin-1β overe ...... in an Alzheimer's mouse model.

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Sustained interleukin-1β overe ...... in an Alzheimer's mouse model.

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Sustained interleukin-1β overe ...... in an Alzheimer's mouse model.

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JNEUROSCI.4361-12.2013

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Journal of Neuroscience

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Sustained interleukin-1β overe ...... in an Alzheimer's mouse model.

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Frank M LaFerla

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John A Olschowka

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M Kerry O'Banion

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Michael D Wu

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Simantini Ghosh

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Solomon S Shaftel

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Stephanos Kyrkanides

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P2860

The role of tau phosphorylation and cleavage in neuronal cell death

Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216

MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics.

Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-amyloid.

Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

Inflammation and Alzheimer's disease

LTP inhibits LTD in the hippocampus via regulation of GSK3beta

The interleukin 1 receptor: ligand interactions and signal transduction

Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway

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5053-5064

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10.1523/JNEUROSCI.4361-12.2013

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11

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2013-03-01T00:00:00Z

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23486975

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Alzheimer's disease

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3637949

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