Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis.
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Targeting BCL2-Proteins for the Treatment of Solid TumoursThe BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer TherapeuticsPotent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax).Dynamin-related protein Drp1 is required for Bax translocation to mitochondria in response to irradiation-induced apoptosisMcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell deathOverexpression of Mcl-1 confers resistance to BRAFV600E inhibitors alone and in combination with MEK1/2 inhibitors in melanoma.Attacking cancer's Achilles heel: antagonism of anti-apoptotic BCL-2 family membersCancer subclonal genetic architecture as a key to personalized medicine.How to unleash mitochondrial apoptotic blockades to kill cancers?Drp1-Dependent Mitochondrial Fission Plays Critical Roles in Physiological and Pathological Progresses in Mammals.Novel regulatory roles of Mff and Drp1 in E3 ubiquitin ligase MARCH5-dependent degradation of MiD49 and Mcl1 and control of mitochondrial dynamics.Therapeutic targeting of Bcl-2 family for treatment of B-cell malignancies.Recent advances in gossypol derivatives and analogs: a chemistry and biology view.DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis.Targeting cell death signalling in cancer: minimising 'Collateral damage'.Intersection of mitochondrial fission and fusion machinery with apoptotic pathways: Role of Mcl-1.Imperatorin acts as a cisplatin sensitizer via downregulating Mcl-1 expression in HCC chemotherapy.Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner.MiR-363 sensitizes cisplatin-induced apoptosis targeting in Mcl-1 in breast cancer.Quantification and Characterization of UVB-Induced Mitochondrial Fragmentation in Normal Primary Human Keratinocytes.PTBP1 modulation of MCL1 expression regulates cellular apoptosis induced by antitubulin chemotherapeutics.BH3 mimetic Obatoclax (GX15-070) mediates mitochondrial stress predominantly via MCL-1 inhibition and induces autophagy-dependent necroptosis in human oral cancer cells.Evaluation and critical assessment of putative MCL-1 inhibitors.
P2860
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P2860
Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Sabutoclax (BI97C1) and BI112D ...... f or independent of apoptosis.
@ast
Sabutoclax (BI97C1) and BI112D ...... f or independent of apoptosis.
@en
type
label
Sabutoclax (BI97C1) and BI112D ...... f or independent of apoptosis.
@ast
Sabutoclax (BI97C1) and BI112D ...... f or independent of apoptosis.
@en
prefLabel
Sabutoclax (BI97C1) and BI112D ...... f or independent of apoptosis.
@ast
Sabutoclax (BI97C1) and BI112D ...... f or independent of apoptosis.
@en
P2093
P2860
P356
P1433
P1476
Sabutoclax (BI97C1) and BI112D ...... f or independent of apoptosis.
@en
P2093
David Dinsdale
Gerald M Cohen
Maurizio Pellecchia
Michael Butterworth
P2860
P304
P356
10.1593/NEO.13230
P577
2013-05-01T00:00:00Z