Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145
about
Haptoglobin, hemopexin, and related defense pathways-basic science, clinical perspectives, and drug developmentHaptoglobin preferentially binds β but not α subunits cross-linked hemoglobin tetramers with minimal effects on ligand and redox reactionsMolecular controls of the oxygenation and redox reactions of hemoglobinRedox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobinMolecular modeling of the human hemoglobin-haptoglobin complex sheds light on the protective mechanisms of haptoglobin.Dissection of the radical reactions linked to fetal hemoglobin reveals enhanced pseudoperoxidase activity.Sickle Cell Hemoglobin in the Ferryl State Promotes βCys-93 Oxidation and Mitochondrial Dysfunction in Epithelial Lung Cells (E10)α-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of α-subunits of human HbA with hydrogen peroxideHemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteinsPost-translational transformation of methionine to aspartate is catalyzed by heme iron and driven by peroxide: a novel subunit-specific mechanism in hemoglobinAtherogenesis may involve the prooxidant and proinflammatory effects of ferryl hemoglobinHaptoglobin Preserves Vascular Nitric Oxide Signaling during HemolysisMechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damageHuman Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity.Antioxidant functions for the hemoglobin β93 cysteine residue in erythrocytes and in the vascular compartment in vivo.Engineering tyrosine electron transfer pathways decreases oxidative toxicity in hemoglobin: implications for blood substitute design.Oxidized Ferric and Ferryl Forms of Hemoglobin Trigger Mitochondrial Dysfunction and Injury in Alveolar Type I Cells.The role of carbon monoxide and heme oxygenase in the prevention of sickle cell disease vaso-occlusive crises.Oxidative pathways in the sickle cell and beyond.Absorbance and redox based approaches for measuring free heme and free hemoglobin in biological matrices.Fetal hemoglobin is much less prone to DNA cleavage compared to the adult protein.Redox reactions of hemoglobin: mechanisms of toxicity and control.Haptoglobin Genotype and Outcome after Subarachnoid Haemorrhage: New Insights from a Meta-Analysis.Mechanisms involved in hemoglobin-mediated oxidation of lipids in washed fish muscle and inhibitory effects of phospholipase A2.Determination of extinction coefficients of human hemoglobin in various redox states.Mechanisms of Toxicity and Modulation of Hemoglobin-Based Oxygen Carriers (HBOCs).Characterization of Protein-Protein Interactions in Recombinant Hemoglobin Producing Escherichia coli Cells Using Molecularly Imprinted Polymers.Hydrogen Sulfide Abrogates Hemoglobin-Lipid Interaction in Atherosclerotic Lesion.Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics.Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction.The Penultimate Tyrosine Residues are Critical for the Genotoxic Effect of Human Hemoglobin.Unique Contribution of Haptoglobin and Haptoglobin Genotype in Aneurysmal Subarachnoid Hemorrhage.Site-directed mutagenesis of cysteine residues alters oxidative stability of fetal hemoglobin
P2860
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P2860
Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Haptoglobin binding stabilizes ...... lobin radical on tyrosine β145
@ast
Haptoglobin binding stabilizes ...... lobin radical on tyrosine β145
@en
type
label
Haptoglobin binding stabilizes ...... lobin radical on tyrosine β145
@ast
Haptoglobin binding stabilizes ...... lobin radical on tyrosine β145
@en
prefLabel
Haptoglobin binding stabilizes ...... lobin radical on tyrosine β145
@ast
Haptoglobin binding stabilizes ...... lobin radical on tyrosine β145
@en
P2093
P2860
P1476
Haptoglobin binding stabilizes ...... lobin radical on tyrosine β145
@en
P2093
Abdu I Alayash
Brandon J Reeder
Chris E Cooper
Dimitri A Svistunenko
Dominik J Schaer
Gary Silkstone
Leif Bulow
Michael T Wilson
Paul W Buehler
P2860
P304
P356
10.1089/ARS.2012.4547.TEST
P577
2012-08-06T00:00:00Z