Extending the analysis of nicotinic receptor antagonists with the study of alpha6 nicotinic receptor subunit chimeras - Wikidata - awgldk - TriplyDB

Extending the analysis of nicotinic receptor antagonists with the study of alpha6 nicotinic receptor subunit chimeras

Extending the analysis of nicotinic receptor antagonists with the study of alpha6 nicotinic receptor subunit chimeras

http://www.wikidata.org/entity/Q36807852

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Nicotinic acetylcholine receptor ligands, a patent review (2006-2011)Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHβE Suggests a Unique Mode of Antagonism Characterization of a Novel -Conotoxin from Conus textile That Selectively Targets 6/ 3 2 3 Nicotinic Acetylcholine Receptors Stable expression and functional characterization of a human nicotinic acetylcholine receptor with α6β2 properties: discovery of selective antagonists Low dose nicotine and antagonism of β2 subunit containing nicotinic acetylcholine receptors have similar effects on affective behavior in mice Nicotine Enhances Excitability of Medial Habenular Neurons via Facilitation of Neurokinin Signaling Analysis of rare variations reveals roles of amino acid residues in the N-terminal extracellular domain of nicotinic acetylcholine receptor (nAChR) alpha6 subunit in the functional expression of human alpha6*-nAChRs.The Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels.Comparison of effects produced by nicotine and the α4β2-selective agonist 5-I-A-85380 on intracranial self-stimulation in rats.Nicotinic Receptors: Role in Addiction and Other Disorders of the Brain.Structural differences determine the relative selectivity of nicotinic compounds for native alpha 4 beta 2*-, alpha 6 beta 2*-, alpha 3 beta 4*- and alpha 7-nicotine acetylcholine receptors Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.Progress and challenges in the study of α6-containing nicotinic acetylcholine receptors.Molecular determinants for competitive inhibition of alpha4beta2 nicotinic acetylcholine receptors.Decreasing nicotinic receptor activity and the spatial learning impairment caused by the NMDA glutamate antagonist dizocilpine in rats.The necessity of α4* nicotinic receptors in nicotine-driven behaviors: dissociation between reinforcing and motor effects of nicotine.Pharmacologically distinct nicotinic acetylcholine receptors drive efferent-mediated excitation in calyx-bearing vestibular afferents Monkey adrenal chromaffin cells express α6β4* nicotinic acetylcholine receptors Investigation of the molecular mechanism of the α7 nicotinic acetylcholine receptor positive allosteric modulator PNU-120596 provides evidence for two distinct desensitized states.Nicotinic acetylcholine receptors in dorsal root ganglion neurons include the α6β4* subtype.Enhanced attenuation of nicotine discrimination in rats by combining nicotine-specific antibodies with a nicotinic receptor antagonist bis-Pyridinium cyclophanes: novel ligands with high affinity for the blood-brain barrier choline transporter.α6 nAChR subunit residues that confer α-conotoxin BuIA selectivity Potential therapeutic uses of mecamylamine and its stereoisomers.Nicotinic receptor activation increases [3H]dopamine uptake and cell surface expression of dopamine transporters in rat prefrontal cortex.Mysterious alpha6-containing nAChRs: function, pharmacology, and pathophysiology.Similar activity of mecamylamine stereoisomers in vitro and in vivo Discriminative Stimulus Properties of S(-)-Nicotine: "A Drug for All Seasons".The coumarin scopoletin potentiates acetylcholine release from synaptosomes, amplifies hippocampal long-term potentiation and ameliorates anticholinergic- and age-impaired memory.The discriminative stimulus effects of i.v. nicotine in rhesus monkeys: Pharmacokinetics and apparent pA2 analysis with dihydro-β-erythroidine.Heterologous expression and nonsense suppression provide insights into agonist behavior at α6β2 nicotinic acetylcholine receptors.Elucidation of molecular impediments in the α6 subunit for in vitro expression of functional α6β4* nicotinic acetylcholine receptors.Characterization of rhythmic Ca2+ transients in early embryonic chick motoneurons: Ca2+ sources and effects of altered activation of transmitter receptors.Repeated nicotine administration robustly increases bPiDDB inhibitory potency at alpha6beta2-containing nicotinic receptors mediating nicotine-evoked dopamine release.Age-related changes in functional postsynaptic nicotinic acetylcholine receptor subunits in neurons of the laterodorsal tegmental nucleus, a nucleus important in drug addiction.Evaluation of structurally diverse neuronal nicotinic receptor ligands for selectivity at the alpha6( *) subtype.The contribution of α4β2 and non-α4β2 nicotinic acetylcholine receptors to the discriminative stimulus effects of nicotine and varenicline in mice.GABAergic Neurons as Putative Neurochemical Substrate Mediating Aversive Effects of Nicotine.

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Extending the analysis of nicotinic receptor antagonists with the study of alpha6 nicotinic receptor subunit chimeras

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2008 nî lūn-bûn

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Extending the analysis of nico ...... inic receptor subunit chimeras

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J.NEUROPHARM.2008.03.010

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Neuropharmacology

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Extending the analysis of nico ...... inic receptor subunit chimeras

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Clare Stokes

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Guangrong Zheng

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J Michael McIntosh

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Linda P Dwoskin

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Peter A Crooks

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Roger L Papke

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Zhenfa Zhang

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P2860

Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia

Analysis of mecamylamine stereoisomers on human nicotinic receptor subtypes

alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors

Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes

Nicotinic receptor function: new perspectives from knockout mice.

Sensitivity to voltage-independent inhibition determined by pore-lining region of the acetylcholine receptor.

Mecamylamine combined with nicotine skin patch facilitates smoking cessation beyond nicotine patch treatment alone.

Neuronal nicotinic receptor alpha 6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain.

Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel.

ABT-089, a neuronal nicotinic receptor partial agonist, for the treatment of attention-deficit/hyperactivity disorder in adults: results of a pilot study.

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1189-1200

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10.1016/J.NEUROPHARM.2008.03.010

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8

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54

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2008-03-28T00:00:00Z

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5404615

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18448138

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2494738

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