Overexpression of the PDZ1 domain of PDZK1 blocks the activity of hepatic scavenger receptor, class B, type I by altering its abundance and cellular localization.
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In Vitro and in Vivo Analysis of the Binding of the C Terminus of the HDL Receptor Scavenger Receptor Class B, Type I (SR-BI), to the PDZ1 Domain of Its Adaptor Protein PDZK1Identification of the PDZ3 Domain of the Adaptor Protein PDZK1 as a Second, Physiologically Functional Binding Site for the C Terminus of the High Density Lipoprotein Receptor Scavenger Receptor Class B Type ICarboxy-terminal deletion of the HDL receptor reduces receptor levels in liver and steroidogenic tissues, induces hypercholesterolemia, and causes fatal heart disease.Novel ENU-induced point mutation in scavenger receptor class B, member 1, results in liver specific loss of SCARB1 protein.The SR-BI partner PDZK1 facilitates hepatitis C virus entry.Role of the adaptor protein PDZK1 in controlling the HDL receptor SR-BICellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones.Normal hepatic cell surface localization of the high density lipoprotein receptor, scavenger receptor class B, type I, depends on all four PDZ domains of PDZK1.PDZK1 binding and serine phosphorylation regulate subcellular trafficking of organic anion transport protein 1a1.Challenges in using cultured primary rodent hepatocytes or cell lines to study hepatic HDL receptor SR-BI regulation by its cytoplasmic adaptor PDZK1Interaction of the human prostacyclin receptor with the PDZ adapter protein PDZK1: role in endothelial cell migration and angiogenesis.High density lipoprotein structure-function and role in reverse cholesterol transport.Regulation of expression and function of scavenger receptor class B, type I (SR-BI) by Na+/H+ exchanger regulatory factors (NHERFs)Noncanonical role of the PDZ4 domain of the adaptor protein PDZK1 in the regulation of the hepatic high density lipoprotein receptor scavenger receptor class B, type I (SR-BI).Genetic variants at the PDZ-interacting domain of the scavenger receptor class B type I interact with diet to influence the risk of metabolic syndrome in obese men and women.The scaffold protein PDZK1 undergoes a head-to-tail intramolecular association that negatively regulates its interaction with EBP50.Metabolic syndrome: evidences for a personalized nutrition.Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactions.Differential basolateral-apical distribution of scavenger receptor, class B, type I in cultured cells and the liver.
P2860
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P2860
Overexpression of the PDZ1 domain of PDZK1 blocks the activity of hepatic scavenger receptor, class B, type I by altering its abundance and cellular localization.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Overexpression of the PDZ1 dom ...... nce and cellular localization.
@ast
Overexpression of the PDZ1 dom ...... nce and cellular localization.
@en
type
label
Overexpression of the PDZ1 dom ...... nce and cellular localization.
@ast
Overexpression of the PDZ1 dom ...... nce and cellular localization.
@en
prefLabel
Overexpression of the PDZ1 dom ...... nce and cellular localization.
@ast
Overexpression of the PDZ1 dom ...... nce and cellular localization.
@en
P2093
P2860
P356
P1476
Overexpression of the PDZ1 dom ...... nce and cellular localization.
@en
P2093
Attilio Rigotti
Ayce Yesilaltay
Kathleen Daniels
Monty Krieger
Olivier Kocher
Sara A Fenske
P2860
P304
22097-22104
P356
10.1074/JBC.M800029200
P407
P577
2008-06-10T00:00:00Z