Structural requirements for enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck.
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Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signalingThe influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activationThe kinase, SH3, and SH2 domains of Lck play critical roles in T-cell activation after ZAP-70 membrane localizationPhosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinaseRole of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signalingLck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid raftsThe activated form of the Lck tyrosine protein kinase in cells exposed to hydrogen peroxide is phosphorylated at both Tyr-394 and Tyr-505Phosphorylation-dependent regulation of T-cell activation by PAG/Cbp, a lipid raft-associated transmembrane adaptorThe phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating LckA weak Lck tail bite is necessary for Lck function in T cell antigen receptor signaling.Sequential requirements of the N-terminal palmitoylation site and SH2 domain of Src family kinases in the initiation and progression of FcepsilonRI signaling.The lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling.Physical and functional interaction of Nef with Lck. HIV-1 Nef-induced T-cell signaling defects.Requirement of the SH3 and SH2 domains for the inhibitory function of tyrosine protein kinase p50csk in T lymphocytes.Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fynRapid T-cell receptor-mediated tyrosine phosphorylation of p120, an Fyn/Lck Src homology 3 domain-binding protein.The SH2 domain is required for stable phosphorylation of p56lck at tyrosine 505, the negative regulatory site.Activated lck tyrosine protein kinase stimulates antigen-independent interleukin-2 production in T cells.The protein tyrosine kinase p56lck is required for triggering NF-kappaB activation upon interaction of human immunodeficiency virus type 1 envelope glycoprotein gp120 with cell surface CD4Myristoylation: An Important Protein Modification in the Immune ResponseCD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influxActivation of the Lck tyrosine protein kinase by hydrogen peroxide requires the phosphorylation of Tyr-394.Differential activation of proliferation and cytotoxicity in human T-cell lymphotropic virus type I Tax-specific CD8 T cells by an altered peptide ligand.Progress towards the development of SH2 domain inhibitors.A high-throughput RNAi screen for detection of immune-checkpoint molecules that mediate tumor resistance to cytotoxic T lymphocytesp56lck interacts via its src homology 2 domain with the ZAP-70 kinase.The protein tyrosine kinase p56lck regulates cell adhesion mediated by CD4 and major histocompatibility complex class II proteins.The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands.Interleukin 2-mediated uncoupling of T cell receptor alpha/beta from CD3 signaling.Myristylation of Pr60gag of the murine AIDS-defective virus is required to induce disease and notably for the expansion of its target cellsTyrosine kinase activity of CD4-associated p56lck may not be required for CD4-dependent T-cell activation.Inhibition of Lck enhances glucocorticoid sensitivity and apoptosis in lymphoid cell lines and in chronic lymphocytic leukemia.The kinase-dependent function of Lck in T-cell activation requires an intact site for tyrosine autophosphorylation.Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor functionSH2 domain function is essential for the role of the Lck tyrosine kinase in T cell receptor signal transduction.T-cell receptor signaling is mediated by transient Lck activity, which is inhibited by inorganic mercury.Regulation of Zap-70 by Src family tyrosine protein kinases in an antigen-specific T-cell line.Interaction of SAP-1, a transmembrane-type protein-tyrosine phosphatase, with the tyrosine kinase Lck. Roles in regulation of T cell function.Defective p56Lck activity in T cells from an adult patient with idiopathic CD4+ lymphocytopenia.Encoding optical control in LCK kinase to quantitatively investigate its activity in live cells.
P2860
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P2860
Structural requirements for enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Structural requirements for en ...... yrosine protein kinase p56lck.
@ast
Structural requirements for en ...... yrosine protein kinase p56lck.
@en
type
label
Structural requirements for en ...... yrosine protein kinase p56lck.
@ast
Structural requirements for en ...... yrosine protein kinase p56lck.
@en
prefLabel
Structural requirements for en ...... yrosine protein kinase p56lck.
@ast
Structural requirements for en ...... yrosine protein kinase p56lck.
@en
P2093
P2860
P356
P1476
Structural requirements for en ...... yrosine protein kinase p56lck.
@en
P2093
P2860
P304
P356
10.1128/MCB.12.6.2720
P407
P577
1992-06-01T00:00:00Z