Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies. - Wikidata - awgldk - TriplyDB

Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies.

Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies.

http://www.wikidata.org/entity/Q36825291

about

Altered ribostasis: RNA-protein granules in degenerative disorders Multiple Aspects of Gene Dysregulation in Huntington's Disease MicroRNA: Implications for Alzheimer Disease and other Human CNS Disorders Who Regulates Whom? An Overview of RNA Granules and Viral Infections The involvement of microRNAs in neurodegenerative diseases Neuronal dark matter: the emerging role of microRNAs in neurodegeneration Current understanding of the role of microRNAs in spinocerebellar ataxias Mammalian microtubule P-body dynamics are mediated by nesprin-1.Huntingtin mediates dendritic transport of β-actin mRNA in rat neurons A role for huntington disease protein in dendritic RNA granules Potential function for the Huntingtin protein as a scaffold for selective autophagy.Is Huntingtin Dispensable in the Adult Brain?Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis.Localization of BDNF mRNA with the Huntington's disease protein in rat brain.Oligonucleotide-based strategies to combat polyglutamine diseases.Defining larger roles for "tiny" RNA molecules: role of miRNAs in neurodegeneration research.A myriad of miRNA variants in control and Huntington's disease brain regions detected by massively parallel sequencing.A pathogenic mechanism in Huntington's disease involves small CAG-repeated RNAs with neurotoxic activity.Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis.MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington's disease-related mechanisms Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes.A combined immunoprecipitation, mass spectrometric and nucleic acid sequencing approach to determine microRNA-mediated post-transcriptional gene regulatory networks.MicroRNAs located in the Hox gene clusters are implicated in huntington's disease pathogenesis.Unraveling regulation and new components of human P-bodies through a protein interaction framework and experimental validation Smaug1 mRNA-silencing foci respond to NMDA and modulate synapse formation.Cause or Effect: Misregulation of microRNA Pathways in Neurodegeneration.Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death.Expression of microRNAs in human post-mortem amyotrophic lateral sclerosis spinal cords provides insight into disease mechanisms Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages.Huntington's Disease Protein Huntingtin Associates with its own mRNA.Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models Short non-coding RNA biology and neurodegenerative disorders: novel disease targets and therapeutics.Searching for MIND: microRNAs in neurodegenerative diseases.Regulation of non-coding RNA networks in the nervous system--what's the REST of the story?Quantifying Argonaute proteins in and out of GW/P-bodies: implications in microRNA activities.Molecular mechanisms and potential therapeutical targets in Huntington's disease.Role of noncoding RNAs in trinucleotide repeat neurodegenerative disorders.Mechanism(s) of alteration of micro RNA expressions in Huntington's disease and their possible contributions to the observed cellular and molecular dysfunctions in the disease.MicroRNAs and neurodegeneration: role and impact.Dendritic protein synthesis in the normal and diseased brain.

P2860

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P2860

Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies.

http://www.wikidata.org/entity/Q36825291

description

2008 nî lūn-bûn

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2008年論文

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2008年論文

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2008年论文

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Huntington's disease protein c ...... n with Argonaute and P bodies.

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PNAS.0800658105

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Proceedings of the National Academy of Sciences of the United States of America

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Huntington's disease protein c ...... on with Argonaute and P bodies

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P2093

Anthony Makusky

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David Baillat

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Dimitri Krainc

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Florian Then

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Jeffrey N Savas

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Ramin Shiekhattar

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Sanford P Markey

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Søren Ottosen

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P2860

Huntingtin interacting proteins are genetic modifiers of neurodegeneration

Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54

Identification of novel argonaute-associated proteins

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules

Polyglutamine expansion of huntingtin impairs its nuclear export

Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

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10820-10825

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31

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105

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18669659

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Huntington disease

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2504805

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