Bone biopsy derived marrow stromal elements rescue chronic lymphocytic leukemia B-cells from spontaneous and drug induced cell death and facilitates an "angiogenic switch".
about
Bone marrow stromal cells protect lymphoma B-cells from rituximab-induced apoptosis and targeting integrin α-4-β-1 (VLA-4) with natalizumab can overcome this resistanceHuman bone marrow mesenchymal stem cells display anti-cancer activity in SCID mice bearing disseminated non-Hodgkin's lymphoma xenograftsThe pathogenic relevance of the prognostic markers CD38 and CD49d in chronic lymphocytic leukemiaCirculating microvesicles in B-cell chronic lymphocytic leukemia can stimulate marrow stromal cells: implications for disease progression.The treatment of recurrent/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) with everolimus results in clinical responses and mobilization of CLL cells into the circulationInfluence of bone marrow stromal microenvironment on forodesine-induced responses in CLL primary cells.Impact of bone marrow stromal cells on Bcl-2 family members in chronic lymphocytic leukemia.Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switch.A combination of cytokines rescues highly purified leukemic CLL B-cells from spontaneous apoptosis in vitro.The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapy.The PI3-kinase delta inhibitor idelalisib (GS-1101) targets integrin-mediated adhesion of chronic lymphocytic leukemia (CLL) cell to endothelial and marrow stromal cellsAn interaction between hepatocyte growth factor and its receptor (c-MET) prolongs the survival of chronic lymphocytic leukemic cells through STAT3 phosphorylation: a potential role of mesenchymal cells in the diseaseChronic lymphocytic leukemia nurse-like cells express hepatocyte growth factor receptor (c-MET) and indoleamine 2,3-dioxygenase and display features of immunosuppressive type 2 skewed macrophages.Bone marrow stromal cell-derived vascular endothelial growth factor (VEGF) rather than chronic lymphocytic leukemia (CLL) cell-derived VEGF is essential for the apoptotic resistance of cultured CLL cellsSelinexor is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemiaSorafenib-induced apoptosis of chronic lymphocytic leukemia cells is associated with downregulation of RAF and myeloid cell leukemia sequence 1 (Mcl-1).CD49d expression is an independent predictor of overall survival in patients with chronic lymphocytic leukaemia: a prognostic parameter with therapeutic potentialTargeted Axl Inhibition Primes Chronic Lymphocytic Leukemia B Cells to Apoptosis and Shows Synergistic/Additive Effects in Combination with BTK Inhibitors.Co-culture of primary CLL cells with bone marrow mesenchymal cells, CD40 ligand and CpG ODN promotes proliferation of chemoresistant CLL cells phenotypically comparable to those proliferating in vivoPhysical contact with endothelial cells through β1- and β2- integrins rescues chronic lymphocytic leukemia cells from spontaneous and drug-induced apoptosis and induces a peculiar gene expression profile in leukemic cells.Impact of oxygen concentration on growth of mesenchymal stromal cells from the marrow of patients with chronic lymphocytic leukemia.Study of the quantitative, functional, cytogenetic, and immunoregulatory properties of bone marrow mesenchymal stem cells in patients with B-cell chronic lymphocytic leukemia.Preclinical modeling of novel therapeutics in chronic lymphocytic leukemia: the tools of the tradeNovel molecular and cellular therapeutic targets in acute lymphoblastic leukemia and lymphoproliferative disease.Pretreatment angiogenic cytokines predict response to chemoimmunotherapy in patients with chronic lymphocytic leukaemia.Bi-directional activation between mesenchymal stem cells and CLL B-cells: implication for CLL disease progressionCurcumin inhibits prosurvival pathways in chronic lymphocytic leukemia B cells and may overcome their stromal protection in combination with EGCG.Critical signal transduction pathways in CLL.Structure and function of the hematopoietic cancer niche: focus on chronic lymphocytic leukemia.Modeling the chronic lymphocytic leukemia microenvironment in vitro.Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance.Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells.Tris (dibenzylideneacetone) dipalladium: a small-molecule palladium complex is effective in inducing apoptosis in chronic lymphocytic leukemia B-cells.RelB, together with RelA, sustains cell survival and confers proteasome inhibitor sensitivity of chronic lymphocytic leukemia cells from bone marrow.CD84 mediates CLL-microenvironment interactions.Two novel aspirin analogues show selective cytotoxicity in primary chronic lymphocytic leukaemia cells that is associated with dual inhibition of Rel A and COX-2.A novel ex vivo high-throughput assay reveals antiproliferative effects of idelalisib and ibrutinib in chronic lymphocytic leukemia.
P2860
Q28243054-BF6E6535-7EF1-4169-B6F1-03154461680BQ33618949-B3817E80-9E75-4045-A523-B2682197136EQ33655756-01EBC227-2CB9-4BBC-A2D3-7A87CB0DA255Q33706349-E3FCC36B-3889-4D03-84A9-70BB7AAEDEFBQ33816583-71990C00-3B46-4217-9413-F532D77D714DQ34122323-BE4D309F-8000-4FC2-8C84-4BFDCC1082FFQ34231324-FA154A7E-A3BE-433A-8890-321C2C45E2EEQ34282342-EBA34C13-8112-4F13-AE64-6C84E4FF7D20Q34653811-81DDA68A-4ACC-426C-A6A8-39CA8470F3A5Q34667753-13009037-2BC5-4A70-A76F-BF71654E2C29Q35078248-EB49CBF0-077D-4320-A95F-7EA2D6F685B1Q35082524-76CC2748-6227-4ABF-B861-77F496B54116Q35100546-91DEDE1B-2358-4FA3-91FD-A36FD3EC3224Q35136736-D825622A-F7FF-4101-91C4-480F1740487EQ35607285-840BE933-3A67-42C3-8A51-D9CA6425BC29Q35718966-4CCC3F15-4F0A-4E84-A168-64E115081652Q35769292-27E8D2B0-6323-458E-877E-87B32A93320CQ35775881-15BA90F6-EEF5-4F64-8297-14993E47DB9CQ35781372-DDA92EB1-1DFC-4E37-B812-CEE985D02C0FQ36006453-F41FEEF0-D297-49B6-A4B0-4162EC897573Q36595313-5F0FBD6E-6E7D-458D-8D78-607B2ACFD102Q36776849-5B3199BA-7C2A-4223-9B5E-E467748D229BQ36867755-57C76C4E-86F1-4676-98F8-9121C9BC109CQ37248354-3F9DB563-0A5C-4ACC-8072-DE343573E438Q37421821-F88574CD-5B8B-44C5-8A72-A48D324DEDADQ37439573-3B3BF83E-852B-44FA-8CB3-A92E9178A1BAQ37483502-1EC94DDB-2892-4569-B168-6FB16A37955EQ37571068-4900E192-AB94-4A02-B234-BCB3CE5B3BA5Q37971736-C7E72479-F89C-41F2-A758-1B183146E805Q38984569-84419BCF-C303-449C-98CF-38E3A2D04812Q39798268-E3DE603E-F748-4F83-BBC3-E9EE29D70231Q39960316-888C2B66-A47A-4B3A-8079-A48030FD91E8Q41652556-479C44D2-EE28-47F2-83AB-9361EE4E8E88Q42444933-01C8E45C-30BF-499D-B412-781166F76BDDQ51620105-3E6AAF44-0992-4629-B692-8A3634E7C545Q54584717-B4150170-A60E-4315-B80D-DE79F3455527Q55061968-55389AAD-DB1F-4138-9E4F-10BA39071C23
P2860
Bone biopsy derived marrow stromal elements rescue chronic lymphocytic leukemia B-cells from spontaneous and drug induced cell death and facilitates an "angiogenic switch".
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Bone biopsy derived marrow str ...... itates an "angiogenic switch".
@en
type
label
Bone biopsy derived marrow str ...... itates an "angiogenic switch".
@en
prefLabel
Bone biopsy derived marrow str ...... itates an "angiogenic switch".
@en
P2093
P2860
P1433
P1476
Bone biopsy derived marrow str ...... itates an "angiogenic switch".
@en
P2093
Ann K Strege
Nancy D Bone
Neil E Kay
Tait D Shanafelt
Yean K Lee
P2860
P304
P356
10.1016/J.LEUKRES.2006.11.024
P577
2007-01-22T00:00:00Z