Degeneration of neurons, synapses, and neuropil and glial activation in a murine Atm knockout model of ataxia-telangiectasia.
about
Generation of bovine transgenics using somatic cell nuclear transferTargeting New Candidate Genes by Small Molecules Approaching Neurodegenerative DiseasesLoss of p53 Ser18 and Atm results in embryonic lethality without cooperation in tumorigenesisThe role of the DNA damage response kinase ataxia telangiectasia mutated in neuroprotectionInvestigation of the functional link between ATM and NBS1 in the DNA damage response in the mouse cerebellum.Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasiaEZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia.Ataxia-telangiectasia, cancer and the pathobiology of the ATM gene.Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/- mice.Ataxia telangiectasia derived iPS cells show preserved x-ray sensitivity and decreased chromosomal instabilityAlteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency.Elevated Cu/Zn-SOD exacerbates radiation sensitivity and hematopoietic abnormalities of Atm-deficient miceSMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs.Reduced synchronization persistence in neural networks derived from atm-deficient mice.ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation.Effects of antioxidants on cancer prevention and neuromotor performance in Atm deficient mice.Stable brain ATM message and residual kinase-active ATM protein in ataxia-telangiectasiaExperimental antioxidant therapy in ataxia telangiectasia.ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila.DNA damage-induced programmed cell death: potential roles in germ cell development.Selective loss of dopaminergic nigro-striatal neurons in brains of Atm-deficient miceCell division in the CNS: protective response or lethal event in post-mitotic neurons?DNA repair abnormalities leading to ataxia: shared neurological phenotypes and risk factors.Neurodegeneration in ataxia-telangiectasia: Multiple roles of ATM kinase in cellular homeostasis.Targeting p38 mitogen-activated protein kinase signaling restores subventricular zone neural stem cells and corrects neuromotor deficits in Atm knockout mouse.Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiencyA role for vascular deficiency in retinal pathology in a mouse model of ataxia-telangiectasia.ATM deficiency induces oxidative stress and endoplasmic reticulum stress in astrocytes.Human iPSC-Derived Cerebellar Neurons from a Patient with Ataxia-Telangiectasia Reveal Disrupted Gene Regulatory Networks.Bone marrow transplantation improves the outcome of Atm-deficient mice through the migration of ATM-competent cells.Malfunctioning DNA damage response (DDR) leads to the degeneration of nigro-striatal pathway in mouse brain.Atm reactivation reverses ataxia telangiectasia phenotypes in vivo.Membrane and transmembrane signaling in Herpesvirus saimiri-transformed human CD4(+) and CD8(+) T lymphocytes is ATM-independent.Variable in vivo embryoprotective role for ataxia-telangiectasia-mutated against constitutive and phenytoin-enhanced oxidative stress in atm knockout mice.Elongator mutation in mice induces neurodegeneration and ataxia-like behavior
P2860
Q24798553-EFB7A411-AD55-4C04-969D-9F8582618703Q26771812-4EC1D3EE-583D-40DD-B628-E339A3970C6DQ28477245-EF19B549-0A83-459A-AE14-F2D5242B474AQ28611424-477950BF-E133-4F24-8E62-F8053DE183E9Q30499891-8AE1E6D6-E13E-4106-B2C2-E7D67431C271Q30516583-B8CD531D-EB7F-4211-89E8-3DF97AF7ECBFQ30574640-6D625702-6089-428C-93BF-CDBA7D7D499BQ33697357-8A24C7F5-FABC-474C-966D-8B19F6E49E6AQ33775092-7EC70921-42BB-4F3F-9E90-F92E82393135Q33813801-E5D40296-C17E-49E2-8EB8-172F928CFFB0Q34499746-E7E6B44F-E4D2-4599-B9DD-BE0719673300Q34584250-5511E2BA-BD4C-4987-9109-1357394662BDQ34709237-45993CDB-9B60-458C-82C1-87C9D12F09C0Q34802470-4F802ED9-0DD9-486E-BDE2-3386C1E57C62Q34980532-96B70606-34ED-4B86-84D5-62875F5099CEQ35021217-76C711FC-4487-4C78-94DE-6E1BDB4833EEQ35029131-88BD0763-4B3E-4F8E-B3FF-A588096F62FAQ35181084-75840F17-9669-4652-B647-2D4604A22131Q35837175-FABDA8E3-9790-407A-BFA8-C1FD26C3E6ACQ36167430-A533D285-AC00-441E-9266-2D53B9582E54Q36528393-9497C692-306D-4B1E-8573-B33F3E17EFC0Q36678493-C13E4AA8-1F8B-49DC-B1E6-7FC060614D92Q38231252-C9FE9DA5-6FC0-4406-84C8-B068D315EFD0Q39329727-5BE702FC-0A49-4461-9A6D-4DF40769DDA7Q40882914-814D6C83-3BDF-458C-BEC7-855B9D86F658Q42771888-BF26F036-D798-41B2-889B-0A0D2C424007Q42869599-DFC74BA6-0A72-433F-97F3-D8D207FB6F5CQ46724717-2390B4A0-6FA1-4410-97FB-6A88D4CEE2E5Q47153351-1C59F146-AEFB-47F4-8BBE-FD4436727054Q48320051-FAC9E615-81C3-4545-B521-3BB7E1069C60Q48895419-6FAF491D-7C01-4F36-8FCC-53CE01B5D808Q51767785-D62E22F6-C9D4-48C1-9F43-F101CB517C95Q52167943-8A8F767A-CE13-4BD9-B39E-A8AABACCBEC3Q53621846-41493D06-A280-4B95-B07D-73F369AF710AQ58790989-AB36B5F5-5DEB-42FF-97BB-FD6C193AEAF8
P2860
Degeneration of neurons, synapses, and neuropil and glial activation in a murine Atm knockout model of ataxia-telangiectasia.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Degeneration of neurons, synap ...... odel of ataxia-telangiectasia.
@en
type
label
Degeneration of neurons, synap ...... odel of ataxia-telangiectasia.
@en
prefLabel
Degeneration of neurons, synap ...... odel of ataxia-telangiectasia.
@en
P2093
P2860
P356
P1476
Degeneration of neurons, synap ...... model of ataxia-telangiectasia
@en
P2093
P2860
P304
12688-12693
P356
10.1073/PNAS.94.23.12688
P407
P50
P577
1997-11-01T00:00:00Z