Probing receptor binding activity of interleukin-8 dimer using a disulfide trap
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Monomeric and dimeric CXCL8 are both essential for in vivo neutrophil recruitmentHuman Macrophage Inflammatory Protein 3 : Protein and Peptide Nuclear Magnetic Resonance Solution Structures, Dimerization, Dynamics, and Anti-Infective PropertiesStructural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12A Model of GAG/MIP-2/CXCR2 Interfaces and Its Functional EffectsIn silico analysis reveals sequential interactions and protein conformational changes during the binding of chemokine CXCL-8 to its receptor CXCR1Chemokine CXCL7 Heterodimers: Structural Insights, CXCR2 Receptor Function, and Glycosaminoglycan InteractionsStructural basis for differential binding of the interleukin-8 monomer and dimer to the CXCR1 N-domain: role of coupled interactions and dynamicsDifferential activation and regulation of CXCR1 and CXCR2 by CXCL8 monomer and dimerProbing the role of CXC motif in chemokine CXCL8 for high affinity binding and activation of CXCR1 and CXCR2 receptorsDissociating quaternary structure regulates cell-signaling functions of a secreted human tRNA synthetaseA fluorescence polarization assay for the experimental validation of an in silico model of the chemokine CXCL8 binding to receptor-derived peptides.The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment.Design and receptor interactions of obligate dimeric mutant of chemokine monocyte chemoattractant protein-1 (MCP-1).Chemokine CXCL1-Mediated Neutrophil Trafficking in the Lung: Role of CXCR2 Activation.Structural basis of chemokine receptor function--a model for binding affinity and ligand selectivityChemokine CXCL1 dimer is a potent agonist for the CXCR2 receptor.Molecular basis of glycosaminoglycan heparin binding to the chemokine CXCL1 dimer.Thermodynamic characterization of interleukin-8 monomer binding to CXCR1 receptor N-terminal domain.The dynamics of interleukin-8 and its interaction with human CXC receptor I peptide.Mechanisms of Regulation of the Chemokine-Receptor Network.Regulation of Chemokine Function: The Roles of GAG-Binding and Post-Translational NitrationSolution NMR characterization of WT CXCL8 monomer and dimer binding to CXCR1 N-terminal domain.Chemokine signaling specificity: essential role for the N-terminal domain of chemokine receptors.Organization and dynamics of the N-terminal domain of chemokine receptor CXCR1 in reverse micelles: effect of graded hydration.Platelet-Derived Chemokine CXCL7 Dimer Preferentially Exists in the Glycosaminoglycan-Bound Form: Implications for Neutrophil-Platelet Crosstalk.Structure of monomeric Interleukin-8 and its interactions with the N-terminal Binding Site-I of CXCR1 by solution NMR spectroscopy.Heparin-bound chemokine CXCL8 monomer and dimer are impaired for CXCR1 and CXCR2 activation: implications for gradients and neutrophil trafficking.Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.The human CC chemokine MIP-1beta dimer is not competent to bind to the CCR5 receptor.
P2860
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P2860
Probing receptor binding activity of interleukin-8 dimer using a disulfide trap
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Probing receptor binding activity of interleukin-8 dimer using a disulfide trap
@en
type
label
Probing receptor binding activity of interleukin-8 dimer using a disulfide trap
@en
prefLabel
Probing receptor binding activity of interleukin-8 dimer using a disulfide trap
@en
P2093
P2860
P356
P1433
P1476
Probing receptor binding activity of interleukin-8 dimer using a disulfide trap
@en
P2093
Gregory N Prado
Harshica Fernando
Ian Clark-Lewis
Krishna Rajarathnam
P2860
P304
P356
10.1021/BI0605944
P407
P50
P577
2006-06-01T00:00:00Z