Amyloid beta ion channel: 3D structure and relevance to amyloid channel paradigm.
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The coexistence of an equal amount of Alzheimer's amyloid-β 40 and 42 forms structurally stable and toxic oligomers through a distinct pathwayCoenzyme Q10 protects human endothelial cells from β-amyloid uptake and oxidative stress-induced injuryCompetitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and ToxicityAmyloid Beta annular protofibrils in cell processes and synapses accumulate with aging and Alzheimer-associated genetic modificationAnnular protofibrils are a structurally and functionally distinct type of amyloid oligomer.Anti-Viral Properties of Amyloid-β Peptides.Aggregation and fibril morphology of the Arctic mutation of Alzheimer's Aβ peptide by CD, TEM, STEM and in situ AFMEffects of membrane interaction and aggregation of amyloid β-peptide on lipid mobility and membrane domain structure.Effect of metals on kinetic pathways of amyloid-β aggregationAmyloid-beta-induced ion flux in artificial lipid bilayers and neuronal cells: resolving a controversyPolymorphism in Alzheimer Abeta amyloid organization reflects conformational selection in a rugged energy landscape.Disordered amyloidogenic peptides may insert into the membrane and assemble into common cyclic structural motifs.Inhibitors of catalase-amyloid interactions protect cells from beta-amyloid-induced oxidative stress and toxicity.Multivariate analyses of amyloid-beta oligomer populations indicate a connection between pore formation and cytotoxicityMembrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer's β-Amyloid Protein.Single-channel Ca(2+) imaging implicates Aβ1-42 amyloid pores in Alzheimer's disease pathologyAnalyzing and Modeling the Kinetics of Amyloid Beta Pores Associated with Alzheimer's Disease Pathology.Seladin-1/DHCR24 protects neuroblastoma cells against Abeta toxicity by increasing membrane cholesterol content.Two-step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formationAmyloid beta oligomers induce neuronal elasticity changes in age-dependent manner: a force spectroscopy study on living hippocampal neurons.Molecular interactions of Alzheimer amyloid-β oligomers with neutral and negatively charged lipid bilayers.Alterations of some membrane transport proteins in Alzheimer's disease: role of amyloid beta-peptide.Distinct Membrane Disruption Pathways Are Induced by 40-Residue β-Amyloid Peptides.K3 fragment of amyloidogenic beta(2)-microglobulin forms ion channels: implication for dialysis related amyloidosis.Calcium dyshomeostasis and neurotoxicity of Alzheimer's beta-amyloid protein.The Function of the Mitochondrial Calcium Uniporter in Neurodegenerative Disorders.Nanoimaging for protein misfolding diseases.Oxidative stress and cell membranes in the pathogenesis of Alzheimer's disease.Disruption of zinc homeostasis and the pathogenesis of senile dementia.Cellular membrane fluidity in amyloid precursor protein processing.Molecular understanding of a potential functional link between antimicrobial and amyloid peptides.Effect of amyloids on the vesicular machinery: implications for somatic neurotransmission.Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients.Mechanism of cholesterol-assisted oligomeric channel formation by a short Alzheimer β-amyloid peptide.Thermodynamically stable amyloid-β monomers have much lower membrane affinity than the small oligomers.Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's diseaseCross talk between neurometals and amyloidogenic proteins at the synapse and the pathogenesis of neurodegenerative diseases.Alzheimer Aβ peptide interactions with lipid membranes: fibrils, oligomers and polymorphic amyloid channels.Synaptic failure and adenosine triphosphate imbalance induced by amyloid-β aggregates are prevented by blueberry-enriched polyphenols extract.Isotope-edited FTIR reveals distinct aggregation and structural behaviors of unmodified and pyroglutamylated amyloid β peptides.
P2860
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P2860
Amyloid beta ion channel: 3D structure and relevance to amyloid channel paradigm.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Amyloid beta ion channel: 3D structure and relevance to amyloid channel paradigm.
@en
type
label
Amyloid beta ion channel: 3D structure and relevance to amyloid channel paradigm.
@en
prefLabel
Amyloid beta ion channel: 3D structure and relevance to amyloid channel paradigm.
@en
P2093
P2860
P1476
Amyloid beta ion channel: 3D structure and relevance to amyloid channel paradigm.
@en
P2093
Arjan P Quist
Ratnesh Lal
P2860
P304
P356
10.1016/J.BBAMEM.2007.04.021
P407
P577
2007-05-03T00:00:00Z