Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl.
about
Mouse models of myelodysplastic syndromes.Cbl and human myeloid neoplasms: the Cbl oncogene comes of age.Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies.Inactivation of Brca2 cooperates with Trp53(R172H) to induce invasive pancreatic ductal adenocarcinomas in mice: a mouse model of familial pancreatic cancerNUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insightsPKR inhibits the DNA damage response, and is associated with poor survival in AML and accelerated leukemia in NHD13 mice.Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndromeGene expression profiling and candidate gene resequencing identifies pathways and mutations important for malignant transformation caused by leukemogenic fusion genes.MSI2 is required for maintaining activated myelodysplastic syndrome stem cells.The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR.Myelodysplastic syndrome: an inability to appropriately respond to damaged DNA?PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia.Molecular bases of myelodysplastic syndromes: lessons from animal models.Age-related epigenetic drift in the pathogenesis of MDS and AML.Epigenetic targets in human neoplasms.Mutations of c-Cbl in myeloid malignanciesOxidative stress leads to increased mutation frequency in a murine model of myelodysplastic syndrome.Non-homologous end joining mediated DNA repair is impaired in the NUP98-HOXD13 mouse model for myelodysplastic syndrome.Progressive genomic instability in the Nup98-HoxD13 model of MDS correlates with loss of the PIG-A gene productAltered follicular helper T cell impaired antibody production in a murine model of myelodysplastic syndromes.Somatic mutations in murine models of leukemia and lymphoma: Disease specificity and clinical relevance.Molecular Diversity and Associated Phenotypic Spectrum of Germline CBL Mutations.Expression of the novel NUP98/PSIP1 fusion transcripts in myelodysplastic syndrome with t(9;11)(p22;p15).
P2860
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P2860
Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Leukemic transformation in mic ...... ations in Nras, Kras, and Cbl.
@en
type
label
Leukemic transformation in mic ...... ations in Nras, Kras, and Cbl.
@en
prefLabel
Leukemic transformation in mic ...... ations in Nras, Kras, and Cbl.
@en
P2093
P2860
P1433
P1476
Leukemic transformation in mic ...... ations in Nras, Kras, and Cbl.
@en
P2093
Christopher Slape
Leah Y Liu
Peter D Aplan
Sarah Beachy
P2860
P304
P356
10.1182/BLOOD-2008-01-135186
P407
P577
2008-06-19T00:00:00Z