A replication-competent, neuronal spread-defective, live attenuated herpes simplex virus type 1 vaccine.
about
A live-attenuated HSV-2 ICP0 virus elicits 10 to 100 times greater protection against genital herpes than a glycoprotein D subunit vaccineHSV-2: in pursuit of a vaccineHerpes simplex virus type 2 glycoprotein E is required for efficient virus spread from epithelial cells to neurons and for targeting viral proteins from the neuron cell body into axons.Pan-HSV-2 IgG antibody in vaccinated mice and guinea pigs correlates with protection against herpes simplex virus 2.A single intramuscular vaccination of mice with the HSV-1 VC2 virus with mutations in the glycoprotein K and the membrane protein UL20 confers full protection against lethal intravaginal challenge with virulent HSV-1 and HSV-2 strains.The herpes simplex virus 1 IgG fc receptor blocks antibody-mediated complement activation and antibody-dependent cellular cytotoxicity in vivo.Immunization with a vaccine combining herpes simplex virus 2 (HSV-2) glycoprotein C (gC) and gD subunits improves the protection of dorsal root ganglia in mice and reduces the frequency of recurrent vaginal shedding of HSV-2 DNA in guinea pigs compaLive attenuated herpes simplex virus 2 glycoprotein E deletion mutant as a vaccine candidate defective in neuronal spread.Herpes Simplex Vaccines: Prospects of Live-attenuated HSV Vaccines to Combat Genital and Ocular infections.Single dose of glycoprotein K (gK)-deleted HSV-1 live-attenuated virus protects mice against lethal vaginal challenge with HSV-1 and HSV-2 and induces lasting T cell memory immune responsesAnterograde spread of herpes simplex virus type 1 requires glycoprotein E and glycoprotein I but not Us9.Immunization with HSV-1 glycoprotein C prevents immune evasion from complement and enhances the efficacy of an HSV-1 glycoprotein D subunit vaccineHSV Recombinant Vectors for Gene Therapy.The ongoing pursuit of a prophylactic HSV vaccine.Herpes simplex virus type 1 glycoprotein E mediates retrograde spread from epithelial cells to neurites.The pUL37 tegument protein guides alpha-herpesvirus retrograde axonal transport to promote neuroinvasion.Attenuated Phenotype and Immunogenic Characteristics of a Mutated Herpes Simplex Virus 1 Strain in the Rhesus Macaque.
P2860
Q21089976-17C4983B-2918-4C86-A430-19585CDD249DQ22306291-3D301DCD-790F-4CB0-8006-510A32ABC605Q34071917-B0707D1A-AEB8-4D08-82CE-B7ABB2CC99EDQ34350019-90C20B3A-A75C-4076-8BC9-5B6014DB45DCQ34414463-DD3D83D4-5111-4B6F-A594-AB5B779B5452Q34742635-E14DA604-2D56-41B2-96C3-963EDECD2F35Q35275146-23DED678-29FB-40B1-9017-85801649B3C2Q35867958-5002D4BB-F480-4BAB-86B8-E6927989930DQ36824210-56CE1869-3E88-4631-8B15-8E3F63E15B0DQ37305004-B681C46C-00C4-4902-A281-41FEDAD4045AQ37333821-B264BB37-8933-42B9-8215-460D2EB83FE3Q37439603-E49F35DD-08BF-493E-A4E7-E11BCB7C30A9Q37787777-E1E136DC-2467-41F9-9161-AE58033914C4Q37991272-1AC3D9E5-1634-4578-8314-0AC89233E352Q39874187-6AA43A6E-78FB-4518-A0B4-6916D20C07FAQ47319444-CF5CB91C-67FB-498D-A1A4-DE3AAC70188EQ55284064-B832274A-7E74-424F-9A66-913A8149ECF1
P2860
A replication-competent, neuronal spread-defective, live attenuated herpes simplex virus type 1 vaccine.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
A replication-competent, neuro ...... simplex virus type 1 vaccine.
@en
type
label
A replication-competent, neuro ...... simplex virus type 1 vaccine.
@en
prefLabel
A replication-competent, neuro ...... simplex virus type 1 vaccine.
@en
P2093
P2860
P356
P1433
P1476
A replication-competent, neuro ...... simplex virus type 1 vaccine.
@en
P2093
Elizabeth E Brittle
Fushan Wang
Harvey M Friedman
John M Lubinski
Ralph M Bunte
P2860
P304
P356
10.1128/JVI.00551-08
P407
P577
2008-06-18T00:00:00Z