Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function.
about
Novel in vitro and mathematical models for the prediction of chemical toxicityXenobiotic, bile acid, and cholesterol transporters: function and regulation.Interaction of oxazaphosphorines with multidrug resistance-associated protein 4 (MRP4).Evaluation of an in vitro toxicogenetic mouse model for hepatotoxicityLower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase.Effect of allyl alcohol on hepatic transporter expression: zonal patterns of expression and role of Kupffer cell functionRegulation of hepatic ABCC transporters by xenobiotics and in disease states.In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System.Regulation of alternative macrophage activation in the liver following acetaminophen intoxication by stem cell-derived tyrosine kinase.Functional role of monocytes and macrophages for the inflammatory response in acute liver injury.Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse model.TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injuryMonocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model.Enhanced hepatotoxicity by acetaminophen in Vanin-1 knockout mice is associated with deficient proliferative and immune responses.Alcohol cirrhosis alters nuclear receptor and drug transporter expression in human liver.Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies.Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Drug-induced liver injury: what was new in 2008?Hepatoprotective activity of methanolic extract of Syzygium jambos (Linn.) leaf against paracetamol intoxicated Wistar albino rats.Primary hepatocyte cultures as prominent in vitro tools to study hepatic drug transporters.Immune mechanisms in acetaminophen-induced acute liver failure.Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis.Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses.Role of Kupffer cells and toll-like receptor 4 in acetaminophen-induced acute liver failure.Macrophages and inflammatory mediators in chemical toxicity: a battle of forces.In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI.Acetaminophen Toxicity Novel Insights into Mechanisms and Future Perspectives.
P2860
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P2860
Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Hepatic Mrp4 induction followi ...... dent on Kupffer cell function.
@en
type
label
Hepatic Mrp4 induction followi ...... dent on Kupffer cell function.
@en
prefLabel
Hepatic Mrp4 induction followi ...... dent on Kupffer cell function.
@en
P2093
P2860
P356
P1476
Hepatic Mrp4 induction followi ...... dent on Kupffer cell function.
@en
P2093
George L Scheffer
José E Manautou
Lauren M Aleksunes
Michael J Goedken
Nathan J Cherrington
Rachel Johnson
Sarah N Campion
P2860
P304
P356
10.1152/AJPGI.00541.2007
P577
2008-06-12T00:00:00Z