Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins.
about
Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and functioncAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytesIsolation and characterization of a novel transcription factor that binds to and activates insulin control element-mediated expressionEvolutionary developmental biology and the problem of variationGlucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activatorRole of transcriptional repressor ICER in cyclic AMP-mediated attenuation of cytokine gene expression in human thymocytesModulation of Tax and PKA-mediated expression of HTLV-I promoter via cAMP response element binding and modulator proteins CREB and CREMNeuroendocrine-specific expression of the human prohormone convertase 1 gene. Hormonal regulation of transcription through distinct cAMP response elementsPax6 and Pdx1 form a functional complex on the rat somatostatin gene upstream enhancerPOU domain transcription factor brain 4 confers pancreatic alpha-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 elementThe LIM domain homeobox gene isl-1 is a positive regulator of islet cell-specific proglucagon gene transcriptionFoxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expressionThe paired homeodomain transcription factor Pax-2 is expressed in the endocrine pancreas and transactivates the glucagon gene promoter.Pax-6 and Cdx-2/3 interact to activate glucagon gene expression on the G1 control element.Differential regulation of the glucagon and insulin I gene promoters by the basic helix-loop-helix transcription factors E47 and BETA2.Glucagon gene transcription is negatively regulated by insulin in a hamster islet cell line.Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine.3T3 cell lines stably expressing Pax6 or Pax6(5a)--a new tool used for identification of common and isoform specific target genesThe role of incretins in glucose homeostasis and diabetes treatment.Insulin but not glucagon gene is silenced in human pancreas-derived mesenchymal stem cellsImpaired glucose homeostasis and neonatal mortality in hepatocyte nuclear factor 3alpha-deficient miceDevelopmental extinction of major histocompatibility complex class II gene expression in plasmocytes is mediated by silencing of the transactivator gene CIITA.Glucagon regulates its own synthesis by autocrine signaling.Homologous DNA sequences and cellular factors are implicated in the control of glucagon and insulin gene expressionActivation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2/3.c-jun inhibits transcriptional activation by the insulin enhancer, and the insulin control element is the target of controlGlucagon gene expression is negatively regulated by hepatocyte nuclear factor 3 beta.Research Resource: Genetic Labeling of Human Islet Alpha Cells.Evolutionary conservation of homeodomain-binding sites and other sequences upstream and within the major transcription unit of the Drosophila segmentation gene engrailedTranscriptional activation of the rat glucagon gene by the cyclic AMP-responsive element in pancreatic islet cells.Identification of a transcriptional enhancer important for enteroendocrine and pancreatic islet cell-specific expression of the secretin geneThe caudal-related homeodomain protein Cdx-2/3 regulates glucagon gene expression in islet cells.Molecular mechanisms of cAMP-regulated gene expression.Insulin regulation of the glucagon gene is mediated by an insulin-responsive DNA element.Mutually exclusive interactions between factors binding to adjacent Sp1 and AT-rich elements regulate gastrin gene transcription in insulinoma cells.Islet-specific proteins interact with the insulin-response element of the glucagon gene.Interaction of Maf transcription factors with Pax-6 results in synergistic activation of the glucagon promoter.Insulin responsiveness of the glucagon gene conferred by interactions between proximal promoter and more distal enhancer-like elements involving the paired-domain transcription factor Pax6.Transcription of the rat glucagon gene by the cyclic AMP response element-binding protein CREB is modulated by adjacent CREB-associated proteins.Characterization of a novel calcium response element in the glucagon gene.
P2860
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P2860
Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
1988年论文
@zh
1988年论文
@zh-cn
name
Alpha-cell-specific expression ...... tions of DNA-binding proteins.
@en
type
label
Alpha-cell-specific expression ...... tions of DNA-binding proteins.
@en
prefLabel
Alpha-cell-specific expression ...... tions of DNA-binding proteins.
@en
P2093
P2860
P356
P1476
Alpha-cell-specific expression ...... tions of DNA-binding proteins.
@en
P2093
D J Drucker
J F Habener
J Philippe
Z Misulovin
P2860
P304
P356
10.1128/MCB.8.11.4877
P407
P577
1988-11-01T00:00:00Z