Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. - Wikidata - awgldk - TriplyDB

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

http://www.wikidata.org/entity/Q36850905

about

Fundamentals of cancer metabolism Evolving Insights on Metabolism, Autophagy, and Epigenetics in Liver Myofibroblasts Pancreatic cancer from bench to bedside: molecular pathways and treatment options KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment Genetics and biology of pancreatic ductal adenocarcinoma Positron Emission Tomography Imaging of Tumor Cell Metabolism and Application to Therapy Response Monitoring Targeting hypoxic response for cancer therapy Lipid metabolic reprogramming in cancer cells Pancreatic Cancer Metabolism: Breaking It Down to Build It Back Up Hepatocyte Growth Factor from a Clinical Perspective: A Pancreatic Cancer Challenge MYC, Metabolism, and Cancer Dysregulated metabolism contributes to oncogenesis Perspectives in the treatment of pancreatic adenocarcinoma Amino acid management in cancer Targeting molecular addictions in cancer The expanding role of yeast in cancer research and diagnosis: insights into the function of the oncosuppressors p53 and BRCA1/2 Expanding antitumor therapeutic windows by targeting cancer-specific nicotinamide adenine dinucleotide phosphate-biogenesis pathways Defining the metabolome: size, flux, and regulation Alternative fuels for cancer cells Redox control of glutamine utilization in cancer Novel therapeutic targets of tumor metabolism Glutamine and cancer: cell biology, physiology, and clinical opportunities Molecular pathways: targeting the dependence of mutant RAS cancers on the DNA damage response Time and Circumstances: Cancer Cell Metabolism at Various Stages of Disease Progression Metabolic rewiring in melanoma Understanding cachexia as a cancer metabolism syndrome ROS homeostasis and metabolism: a dangerous liason in cancer cells Drugging the addict: non-oncogene addiction as a target for cancer therapy Metabolic consequences of oncogenic IDH mutations Metabolic pathways promoting cancer cell survival and growth A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth NOX1 supports the metabolic remodeling of HepG2 cells Apolipoprotein A-II Plus Lipid Emulsion Enhance Cell Growth via SR-B1 and Target Pancreatic Cancer In Vitro and In Vivo Identification of KCa3.1 Channel as a Novel Regulator of Oxidative Phosphorylation in a Subset of Pancreatic Carcinoma Cell Lines Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer Soluble factors from stellate cells induce pancreatic cancer cell proliferation via Nrf2-activated metabolic reprogramming and ROS detoxification Pancreatic cancer: yesterday, today and tomorrow.Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth.Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors.

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P2860

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

http://www.wikidata.org/entity/Q36850905

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2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

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name

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

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type

label

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway.

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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

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Alec C Kimmelman

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Cristina R Ferrone

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Edouard Mullarky

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Haoqiang Ying

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Jaekyoung Son

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Jason B Fleming

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John M Asara

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Marcia C Haigis

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Matteo Ligorio

http://www.w3.org/2001/XMLSchema#string

Nabeel Bardeesy

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P2860

Full-length human glutaminase in complex with an allosteric inhibitor

Links between metabolism and cancer

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

Regulation of cancer cell metabolism

Pancreatic cancer

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

Metabolic reprogramming: a cancer hallmark even warburg did not anticipate

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

Pancreatic cancers require autophagy for tumor growth

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101-105

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10.1038/NATURE12040

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7443

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496

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Lewis C. Cantley

Costas A Lyssiotis

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2013-03-27T00:00:00Z

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236087069

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1005310785

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23535601

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3656466

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