A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.
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Genetic Factors in Systemic Lupus Erythematosus: Contribution to Disease PhenotypeRecent advances in the genetics of autoimmune diseaseEmerging therapies for systemic lupus erythematosus--focus on targeting interferon-alphaAssociation of STAT4 polymorphisms with susceptibility to type-1 autoimmune hepatitis in the Japanese populationGenetics and beyond--the transcriptome of human monocytes and disease susceptibilityDifferential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.Replication of recently identified systemic lupus erythematosus genetic associations: a case-control study.Advances in systems biology approaches for autoimmune diseasesThe genetics and epigenetics of autoimmune diseases.Genetic regulation of serum cytokines in systemic lupus erythematosusA single-nucleotide polymorphism of the STAT4 gene is associated with systemic lupus erythematosus (SLE) in female Chinese population.Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.Regulation of IFN response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatmentLack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus.Interferon alpha in systemic lupus erythematosusmTOR signaling: a central pathway to pathogenesis in systemic lupus erythematosus?Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus.Activation of type I interferon pathway in systemic lupus erythematosus: association with distinct clinical phenotypes.Genetic associations in type I interferon related pathways with autoimmunityFurther evidence of subphenotype association with systemic lupus erythematosus susceptibility loci: a European cases only studyA link between interferon and augmented plasmin generation in exocrine gland damage in Sjögren's syndrome.Genomic alterations in abnormal neutrophils isolated from adult patients with systemic lupus erythematosusA candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE.Genetic variants of STAT4 are associated with ankylosing spondylitis susceptibility and severity in a Chinese Han populationAssociation of STAT4 polymorphism with severe renal insufficiency in lupus nephritis.Association of IRF5 polymorphisms with activation of the interferon alpha pathwayGenetic susceptibility to systemic lupus erythematosus in the genomic eraChitinases in the salivary glands and circulation of patients with Sjögren's syndrome: macrophage harbingers of disease severity.The type I interferon system in the etiopathogenesis of autoimmune diseases.Aspects of innate immunity in Sjögren's syndrome.Effects of IRF5 lupus risk haplotype on pathways predicted to influence B cell functionsRole of cytokines in systemic lupus erythematosus: recent progress from GWAS and sequencing.Contribution of STAT4 gene single-nucleotide polymorphism to systemic lupus erythematosus in the Polish populationSTAT4 regulates antiviral gamma interferon responses and recurrent disease during herpes simplex virus 2 infection.The genetics of lupus: a functional perspective.The type I interferons: Basic concepts and clinical relevance in immune-mediated inflammatory diseases.Genetics of SLE: functional relevance for monocytes/macrophages in diseaseB cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice.Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region.Targeted screening of cis-regulatory variation in human haplotypes.
P2860
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P2860
A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
A risk haplotype of STAT4 for ...... with two risk alleles of IRF5.
@en
type
label
A risk haplotype of STAT4 for ...... with two risk alleles of IRF5.
@en
prefLabel
A risk haplotype of STAT4 for ...... with two risk alleles of IRF5.
@en
P2093
P2860
P50
P356
P1476
A risk haplotype of STAT4 for ...... with two risk alleles of IRF5.
@en
P2093
Anders A Bengtsson
Andreas Jönsen
Catharina Eriksson
Elin Grundberg
Gunnar Alm
Gunnar Sturfelt
Gunnel Nordmark
Harald H H Göring
Iva Gunnarsson
Lars Rönnblom
P2860
P304
P356
10.1093/HMG/DDN184
P50
P577
2008-06-25T00:00:00Z