The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults. - Wikidata - awgldk - TriplyDB

The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults.

The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults.

http://www.wikidata.org/entity/Q36855347

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Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder Molecular mechanisms underlying behaviors related to nicotine addiction Genetic vulnerability and susceptibility to substance dependence.A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction.Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population Alternative CHRNB4 3'-UTRs mediate the allelic effects of SNP rs1948 on gene expression Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence.Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population.Common and unique biological pathways associated with smoking initiation/progression, nicotine dependence, and smoking cessation.How can we use our knowledge of alcohol-tobacco interactions to reduce alcohol use?Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice.Modulation of ethanol consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice.Nicotinic receptor ligands reduce ethanol intake by high alcohol-drinking HAD-2 rats.Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research.Subtypes of nicotinic acetylcholine receptors in nicotine reward, dependence, and withdrawal: evidence from genetically modified mice.The genetic components of alcohol and nicotine co-addiction: from genes to behavior The alpha 3 subunit gene of the nicotinic acetylcholine receptor is a candidate gene for ethanol stimulation Association of parents' alcohol use and family interaction with the initiation of alcohol use by sixth graders: a preliminary study in Taiwan.CHRNA5 and CHRNA3 variants and level of neuroticism in young adult Mexican American men and women.Overexpression and activation of the alpha9-nicotinic receptor during tumorigenesis in human breast epithelial cells.Familial aggregation of tobacco use behaviors among Amish men.Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse.Association of CHRN genes with "dizziness" to tobacco.SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample.Clinical features of drug abuse that reflect genetic risk.Developmental excitation of corticothalamic neurons by nicotinic acetylcholine receptors.Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals.The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer Neuronal nicotinic acetylcholine receptors: common molecular substrates of nicotine and alcohol dependence.Nicotinic α5 receptor subunit mRNA expression is associated with distant 5' upstream polymorphisms.The nicotinic acetylcholine receptor alpha5 subunit plays a key role in attention circuitry and accuracy.Associations between variation in CHRNA5-CHRNA3-CHRNB4, body mass index and blood pressure in the Northern Finland Birth Cohort 1966 Scientific overview: 2013 BBC plenary symposium on tobacco addiction.Partial agonists of the α3β4* neuronal nicotinic acetylcholine receptor reduce ethanol consumption and seeking in rats.The α5 subunit regulates the expression and function of α4*-containing neuronal nicotinic acetylcholine receptors in the ventral-tegmental area

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The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults.

http://www.wikidata.org/entity/Q36855347

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J.BIOPSYCH.2007.10.024

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Biological Psychiatry

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The CHRNA5/A3/B4 gene cluster ...... co initiation in young adults.

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Allan C Collins

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Christian J Hopfer

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Isabel R Schlaepfer

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Jeffrey M Lessem

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John K Hewitt

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Marissa A Ehringer

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Matthew B McQueen

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Robin P Corley

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Haploview: analysis and visualization of LD and haplotype maps

A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other.

Genetic and environmental influences on behavioral disinhibition.

In vivo RNA-RNA duplexes from human alpha3 and alpha5 nicotinic receptor subunit mRNAs.

Childhood maltreatment, subsequent antisocial behavior, and the role of monoamine oxidase A genotype.

WHAP: haplotype-based association analysis.

Shared genetic vulnerability in alcohol and cigarette use and dependence.

Neurochemical and behavioral studies on ethanol and nicotine interactions.

Epidemiologic analysis of alcohol and tobacco use.

Smoking and the genetic contribution to alcohol-dependence risk.

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