Engineered recombinant human paraoxonase 1 (rHuPON1) purified from Escherichia coli protects against organophosphate poisoning
about
Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicityParaoxonase-1 and early-life environmental exposuresThe human paraoxonase gene cluster as a target in the treatment of atherosclerosisInflammation, infection, cancer and all that…the role of paraoxonasesCaenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins.Neurobehavioral assessment of mice following repeated postnatal exposure to chlorpyrifos-oxon.The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 statusHuman PON1, a biomarker of risk of disease and exposureProtein adducts as biomarkers of exposure to organophosphorus compoundsRepeated developmental exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects on cerebellar gene expressionSystematic analysis of secreted proteins reveals synergism between IL6 and other proteins in soft agar growth of MCF10A cellsStereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers.Engineering human PON1 in an E. coli expression system.Pharmacological and dietary modulators of paraoxonase 1 (PON1) activity and expression: the hunt goes on.Relationship between paraoxonase and homocysteine: crossroads of oxidative diseases.Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro.Toward Understanding the Catalytic Mechanism of Human Paraoxonase 1: Site-Specific Mutagenesis at Position 192Catalytic bioscavengers against toxic esters, an alternative approach for prophylaxis and treatments of poisonings.Identification of Critical Paraoxonase 1 Residues Involved in High Density Lipoprotein InteractionHuman paraoxonase 1 hydrolysis of nanomolar chlorpyrifos-oxon concentrations is unaffected by phenotype or Q192R genotype.PON1 multitasks to protect health.Characterization of human paraoxonase 1 variants suggest that His residues at 115 and 134 positions are not always needed for the lactonase/arylesterase activities of the enzyme.Pharmacogenetics of paraoxonase activity: elucidating the role of high-density lipoprotein in disease.Organophosphorus hydrolase as an in vivo catalytic nerve agent bioscavenger.Organophosphate-Hydrolyzing Enzymes as First-Line of Defence Against Nerve Agent-Poisoning: Perspectives and the Road Ahead.Adenovirus-mediated human paraoxonase1 gene transfer to provide protection against the toxicity of the organophosphorus pesticide toxicant diazoxon.Dramatic differences in organophosphorus hydrolase activity between human and chimeric recombinant mammalian paraoxonase-1 enzymes.Solubilization and humanization of paraoxonase-1Paraoxonases-1, -2 and -3: What are their functions?Rational design of paraoxonase 1 (PON1) for the efficient hydrolysis of organophosphates.Resveratrol fails to provide prophylactic protection in a rat model of organophosphate poisoning.Enzymatic detoxification of organophosphorus pesticides and related toxicantsHuman paraoxonase 1 as a pharmacologic agent: limitations and perspectives
P2860
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P2860
Engineered recombinant human paraoxonase 1 (rHuPON1) purified from Escherichia coli protects against organophosphate poisoning
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Engineered recombinant human p ...... inst organophosphate poisoning
@en
type
label
Engineered recombinant human p ...... inst organophosphate poisoning
@en
prefLabel
Engineered recombinant human p ...... inst organophosphate poisoning
@en
P2093
P2860
P356
P1476
Engineered recombinant human p ...... inst organophosphate poisoning
@en
P2093
Clement E Furlong
Rebecca J Richter
Richard C Stevens
Sarah S Park
Stephanie M Suzuki
Toby B Cole
P2860
P304
12780-12784
P356
10.1073/PNAS.0805865105
P407
P577
2008-08-18T00:00:00Z