When poor solubility becomes an issue: from early stage to proof of concept.
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Nanotechnology-based drug delivery systems for the treatment of Alzheimer's diseaseRole of Components in the Formation of Self-microemulsifying Drug Delivery SystemsMicro/nanofabricated platforms for oral drug deliveryRelease of a Poorly Soluble Drug from Hydrophobically Modified Poly (Acrylic Acid) in Simulated Intestinal FluidsH2S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair.Advances in improving the quality and flexibility of compound management.Exploratory analysis of kinetic solubility measurements of a small molecule libraryThe use of biorelevant dissolution media to forecast the in vivo performance of a drug.A bifunctional dimethylsulfoxide substitute enhances the aqueous solubility of small organic molecules.In vitro lipolysis data does not adequately predict the in vivo performance of lipid-based drug delivery systems containing fenofibrate.Pharmacokinetic optimization of 4-substituted methoxybenzoyl-aryl-thiazole and 2-aryl-4-benzoyl-imidazole for improving oral bioavailability.Role of medium-chain fatty acids in the emulsification mechanistics of self-micro-emulsifying lipid formulationsCan formulation and drug delivery reduce attrition during drug discovery and development-review of feasibility, benefits and challenges.Ribonucleoside 3'-phosphates as pro-moieties for an orally administered drug.Preparation and evaluation of self-nanoemulsifying tablets of carvedilol.Advances in the pulmonary delivery of poorly water-soluble drugs: influence of solubilization on pharmacokinetic properties.Nanomedicinal strategies to treat multidrug-resistant tumors: current progress.Lipid-based oral multiparticulate formulations - advantages, technological advances and industrial applications.Solid dispersions, part I: recent evolutions and future opportunities in manufacturing methods for dissolution rate enhancement of poorly water-soluble drugs.Excipients with specialized functions for effective drug delivery.Potentials and challenges in self-nanoemulsifying drug delivery systems.Selecting oral bioavailability enhancing formulations during drug discovery and development.Alginate Particles as Platform for Drug Delivery by the Oral Route: State-of-the-Art.Novel tactics for designing water-soluble molecules in drug discovery.Modeling of the pharmacokinetic/pharmacodynamic interaction between irbesartan and hydrochlorothiazide in normotensive subjects.In silico ADME/T modelling for rational drug design.Electrophoretic separation techniques and their hyphenation to mass spectrometry in biological inorganic chemistry.Biophysics: for HTS hit validation, chemical lead optimization, and beyond.Influence of Copolymer Composition on In Vitro and In Vivo Performance of Celecoxib-PVP/VA Amorphous Solid Dispersions.Self-Microemulsifying Drug Delivery Systems: An Attractive Strategy for Enhanced Therapeutic Profile.Formulation and development of a self-nanoemulsifying drug delivery system of irbesartan.The influence of non-ionisable excipients on precipitation parameters measured using the CheqSol method.Quantifying and Communicating Uncertainty in Preclinical Human Dose-Prediction.The influence of bile salts on the distribution of simvastatin in the octanol/buffer system.Exploratory Studies With BT-11: A Proposed Orally Active Therapeutic for Crohn's Disease.Surfactants modify the release from tablets made of hydrophobically modified poly (acrylic acid)Mucoadhesive nanogels by ionotropic crosslinking of chitosan-g-oligo(NiPAam) polymeric micelles as novel drug nanocarriers.The utility of self-emulsifying oil formulation to improve the poor solubility of the anti HIV drug CSIC.Design and development of a self-nanoemulsifying drug delivery system for telmisartan for oral drug delivery.Influence of Milling Process on Efavirenz Solubility.
P2860
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P2860
When poor solubility becomes an issue: from early stage to proof of concept.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
When poor solubility becomes an issue: from early stage to proof of concept.
@en
type
label
When poor solubility becomes an issue: from early stage to proof of concept.
@en
prefLabel
When poor solubility becomes an issue: from early stage to proof of concept.
@en
P2093
P1476
When poor solubility becomes an issue: from early stage to proof of concept.
@en
P2093
P304
P356
10.1016/J.EJPS.2007.05.110
P407
P577
2007-05-21T00:00:00Z